The effect of modification of sympathetic activity on responses to ligation of a coronary artery in the conscious rat

British Journal of Pharmacology
J H BottingM J Walker

Abstract

1 Ligation of a coronary artery was performed in conscious rats whose sympathetic system activity had been altered by various treatments. 2 beta-Adrenoceptor blockade with acute (0.2 mg kg-1 plus 0.1 micrograms kg-1 min-1) or chronic (50-60 mg kg-1 daily for 12 days) propranolol treatment had little effect on arrhythmias, or other responses to ligation. 3 Abrupt withdrawal of chronic propranolol two days before ligation was also without effect. 4 Reduction of sympathetic activity acutely with labetalol (5 mg kg-1), or chronically with adrenomedullectomy and 6-hydroxydopamine treatment, accentuated the adverse effects of ligation. 5 The results of this study suggest that, while activity of the sympathetic system is not detrimental during ligation in the conscious rat, it may be important for survival.

Citations

May 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B A MacLeodM J Walker
Nov 10, 1987·European Journal of Pharmacology·M InoueM Fujiwara
Nov 15, 1988·European Journal of Pharmacology·R ReichhalterW Kobinger
Jul 17, 1990·European Journal of Pharmacology·R G SchoemakerJ F Smits
Jan 1, 1985·Molecular Aspects of Medicine·J H BottingM J Walker
Nov 1, 1995·Clinical and Experimental Pharmacology & Physiology·L N Maslov, Y B Lishmanov
Jan 22, 2009·British Journal of Pharmacology·Hugh Clements-JeweryM J Curtis
Oct 1, 1984·British Journal of Pharmacology·M J CurtisM J Walker
Apr 7, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·Laura A HundahlThomas Jespersen
Jan 1, 1990·Basic Research in Cardiology·R G SchoemakerJ F Smits

Related Concepts

Adrenalectomy
Adrenergic beta-Antagonists
Metazoa
Cardiac Arrhythmia
Diastolic Blood Pressure
Sinus Node Artery
Electrocardiographic Recorders
Pulse Rate
Hydroxydopamine
Ligature

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