PMID: 8961158Nov 1, 1996Paper

The effect of moisture on the heckel and energy analysis of hydroxypropylmethylcellulose 2208 (HPMC K4M)

The Journal of Pharmacy and Pharmacology
A NokhodchiM H Rubinstein

Abstract

The influence of moisture content on the Heckel analysis, energy analysis and strain-rate sensitivity of hydroxyproplymethylcellulose 2208 (HPMC K4M) has been evaluated. An increase in moisture content from 0 to 14.9% w/w decreased the mean yield pressure, probably due to a plasticizing effect of moisture which reduced the resistance of particles to deformation. For each moisture content (0, 2.2, 3.8, 5.9, 9.6 and 14.9% w/w), the initial relative density and the extrapolated density from the linear portion of the Heckel plot, tended to decrease with increasing compression speed. Minor changes were observed in the initial relative density due to changes in the moisture content. The strain-rate sensitivity increased from 21.6 to 50.7% as the moisture content increased from 0 to 14.9% w/w, indicating that the plasticity of HPMC increased with increase in moisture content, whereas increase in moisture content from 0 to 14.9% w/w decreased the plastic energy. Increase in compression force or speed of compaction increased both the plastic and elastic energies. An increase in moisture content from 0 to 5.9% w/w slightly reduced the elastic energy but above 5.9% moisture content the elastic energy was unaffected by the moisture content.

References

Jan 1, 1978·The Journal of Pharmacy and Pharmacology·P York
Jun 1, 1985·The Journal of Pharmacy and Pharmacology·R J Roberts, R C Rowe
Nov 1, 1996·The Journal of Pharmacy and Pharmacology·A NokhodchiM H Rubinstein

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Citations

Jun 8, 2007·Pharmaceutical Research·Kazuyuki ShimizuYukiharu Nakayama
Mar 8, 2000·International Journal of Pharmaceutics·C Alvarez-LorenzoA Concheiro
Jan 6, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·C GustafssonC Nyström
Dec 1, 2005·Drug Development and Industrial Pharmacy·M L VuebaMaria Eugénia Pina
May 26, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Filip KiekensJean Paul Remon
Apr 21, 2016·Drug Development and Industrial Pharmacy·Peter GrdešičIlija Ilić
May 20, 2005·The Journal of Pharmacy and Pharmacology·Chi L LiMatthew Roberts
Jun 25, 2019·Journal of Pharmaceutical Sciences·Rahul Roopwani, Ira S Buckner
May 1, 1997·Journal of Pharmaceutical Sciences·A NokhodchiM H Rubinstein

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