PMID: 15248005Jul 13, 2004Paper

The effect of montelukast sodium on the duration of effusion of otitis media

Clinical Pediatrics
J T Combs

Abstract

This study tests the hypothesis that montelukast sodium, a selective leukotriene receptor antagonist, will decrease the duration of the effusion of otitis media. Tympanometry and spectral gradient acoustic reflectometry were used to confirm the effusion of otitis media in patients between 2 and 12 years of age. Patients were treated with amoxicillin for 10 days and montelukast sodium or placebo for 30 days in a random, double-blind manner. Sixty patients completed the study: 31 received placebo and 29 received montelukast sodium. At a 4-week follow-up visit, 5 ears (16%) were free of effusion in the placebo group and 17 (58%) in the montelukast sodium group. The difference was significant. The efficacy of montelukast sodium in clearing the effusion was 49%.

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Citations

Jul 11, 2006·Current Allergy and Asthma Reports·Deborah Gentile
Sep 21, 2013·Medical Science Monitor Basic Research·Seçil UçarArzu Didem Yalcin
Nov 3, 2010·International Journal of Pediatric Otorhinolaryngology·Giray AynaliSami Gümüş
Jul 3, 2016·International Journal of Pediatric Otorhinolaryngology·Yoshihisa NakamuraShingo Murakami
Oct 27, 2016·Current Allergy and Asthma Reports·Michael P PlattJohn H Krouse
Jun 13, 2016·The Cochrane Database of Systematic Reviews·Roderick P VenekampAnne G M Schilder
May 13, 2009·Clinical and Experimental Otorhinolaryngology·Steven K JuhnTina Huang
Sep 1, 2005·Expert Review of Clinical Immunology·Leif Bjermer

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