The effect of morphine and some other narcotic analgesics on brain tryptophan concentrations

Journal of Neuroscience Research
A W Crossley, P Slater

Abstract

An acute dose of morphine increased brain tryptophan in mice. This effect was not prevented by naloxone nor was it produced by other narcotic analgesics. Dextrorphan, but not levorphanol, had a similar effect to morphine. A large dose of tryptophan had no effect on the antinociceptive action of morphine in mice. Morphine increased brain tryptophan in rats. This effect was prevented by naloxone. A large dose of tryptophan antagonised the antinociceptive action of morphine in the rat.

References

Nov 1, 1976·British Journal of Pharmacology·P K Dey, W Feldberg
Jan 1, 1968·Acta Physiologica Scandinavica·I EngbergR W Ryall
Oct 20, 1972·Nature·P J Knott, G Curzon
Oct 26, 1973·Brain Research·H K Proudfit, E G Anderson
Sep 1, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·G G YarbroughE Sanders-Bush
Jul 1, 1969·British Journal of Pharmacology·K J Rogers, J A Thornton
Jun 20, 1964·Nature·N E ANDENA LUNDBERG

Citations

Jul 1, 1982·Journal of Psychoactive Drugs·T M McGuire
Jan 1, 1989·Journal of Psychoactive Drugs·M Winkelman, M Dobkin De Rios
Aug 20, 2003·Journal of Psychoactive Drugs·Benjamin Thomas

Related Concepts

Opioids
Brain
Dextrorphan
Levo-Dromoran
Morphine Sulfate (2: 1), Pentahydrate
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
PMS-Tryptophan

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