The effect of morphine dependence on impulsive choice in rats.

Psychopharmacology
Colin Harvey-LewisKeith B J Franklin

Abstract

In the human opiate-dependent population, the most consistently reported deficit in executive functioning is impulsivity. Previous research has shown that acute and chronic exposure to drugs of abuse can increase impulsive choice; however, the extent to which opiate dependence contributes to increased impulsivity has not been examined. We report here the effects of morphine dependence on rats' delay discounting (DD) of a sucrose reward. We assigned rats randomly to either a dependent group that received a nightly 30 mg/kg subcutaneous dose of morphine or a morphine-naive group that received a nightly saline injection. DD of a sucrose reward was examined in rats prior to initiation of the dosing regimen, 22.5 h after the daily maintenance dose, and after a 14-day abstinence period. The groups did not differ at baseline, but rats showed accelerated DD while dependent on morphine. After withdrawal from morphine, DD in previously dependent rats was not significantly different from that of naive rats. Since dependent rats also showed reduced motivation to acquire the sucrose reinforcer, we performed a separate experiment to test whether such a decrease in motivation could cause an increase in impulsivity. We found that food-deprived...Continue Reading

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Citations

Feb 19, 2014·Psychopharmacology·Colin Harvey-LewisKeith B J Franklin
Sep 30, 2014·Peptides·Richard J Bodnar
Feb 14, 2015·Current Addiction Reports·Jessica WeaferHarriet de Wit
Sep 5, 2012·Journal of Pharmacological and Toxicological Methods·David R MaguireCharles P France
Aug 2, 2014·Addiction Biology·Kate M WassumSean B Ostlund
Oct 29, 2014·Behavioural Pharmacology·Colin Harvey-LewisKeith B J Franklin
Sep 6, 2014·Psychopharmacology·Colin Harvey-Lewis, Keith B J Franklin
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Kathryn BiernackiPeter G Rendell
Sep 30, 2016·Psychopharmacology·Maria E SecciLeigh V Panlilio
Aug 8, 2019·Psychiatry Investigation·Sema Baykara, Kübra Alban
Sep 28, 2017·Behavioural Pharmacology·Vanessa Minervini, Charles P France
Oct 24, 2018·Psychopharmacology·Parisa MoazenSaeed Semnanian

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