PMID: 6716097Jan 1, 1984

The effect of morphine on 5-hydroxytryptamine and catecholamine neurons in the rat brain. Histofluorescence studies

Journal of Neural Transmission
M Smiałowska, A Bal

Abstract

The effect of acute morphine injection (4 or 40 mg/kg, i.p.) on serotonergic (5-HT) and catecholaminergic (CA) neurons in several areas of the rat brain was studied using the Falck-Hillarp histofluorescence method. Changes in fluorescence intensity (i.e. the changes in amine content) were only found in a few discrete regions. Biphasic changes occurred; an initial decrease (after 40 min) was followed by an increase (after 90 min) in amine content of 5-HT nerve cell bodies and CA terminals in the dorsal raphe nucleus and in the region of group B3. Increases were also observed after 90 min in 5-HT nerve cell bodies in the median raphe nucleus and terminals in the nucleus linearis caudalis, and in CA nerve cell bodies in the pars compacta of the substantia nigra and the ventral tagmental area. No significant changes in fluorescence were observed after two weeks chronic morphine treatment. The changes in fluorescence after acute morphine treatment occurred in structures involved in analgesic function. The time-course of these changes suggests that morphine increases both the release and synthesis of 5-HT and CA in these structures.

References

Oct 1, 1976·Japanese Journal of Pharmacology·A Sawa, T Oka
Feb 21, 1977·European Journal of Pharmacology·Tony L YakshThomas A Rudy
May 1, 1979·Pharmacological Research Communications·F MirandaR Samanin
Jan 1, 1979·Journal of Neuroscience Research·A W Crossley, P Slater
Jan 1, 1975·The Journal of Pharmacy and Pharmacology·B Costall, R J Naylor
Dec 1, 1971·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P Lidbrink, G Jonsson
Nov 1, 1972·European Journal of Pharmacology·B D Görlitz, H H Frey
Nov 1, 1971·European Journal of Pharmacology·R Samanin, L Valzelli
Dec 1, 1966·Japanese Journal of Pharmacology·H Takagi, M Nakama
Sep 1, 1970·European Journal of Pharmacology·J R Lee, M R Fennessy
Sep 1, 1968·Journal of Neurochemistry·B G LivettL Austin
Jul 1, 1966·Acta Physiologica Scandinavica·A Dahlström, J Häggendal
Mar 1, 1964·Acta Physiologica Scandinavica·A DAHLSTROEM, K FUXE
Feb 9, 1965·Zeitschrift für Zellforschung und mikroskopische Anatomie·K FUXE

Citations

Apr 1, 1987·Brain Research Bulletin·R S Root-Bernstein
Apr 7, 2011·Neuropharmacology·L G KirbyC A Winstanley

Related Concepts

Brain Chemistry
Catecholamines
Immunofluorescence Microscopy
Morphine Sulfate (2: 1), Pentahydrate
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Neurons
Raphe Nuclei
August Rats
Hydroxytryptamine

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.