The effect of mosapride on esophageal motility and bolus transit in asymptomatic volunteers

Journal of Clinical Gastroenterology
Yu Kyung ChoIn-Sik Chung

Abstract

To evaluate the effect of mosapride, a selective 5-hydroxytryptamine-4 agonist, on esophageal motility and bolus transit in asymptomatic volunteers. Twenty healthy subjects participated in two experiments, 7 days apart, and we utilized a randomized, double-blind cross-over design with 3-day pretreatments of placebo or mosapride. All subjects underwent combined intraluminal impedance manometry. There was no difference in the amplitude, the duration, and the esophageal peristaltic patterns between the two pretreatments. The lower esophageal sphincter (LES) pressure and the number of transient LES relaxations did not change after mosapride vs. placebo. However, the rate of complete bolus transit in liquid swallows was higher with mosapride pretreatment (92.2%) than with placebo (84.6%; P < 0.01). The total bolus transit time in all liquid swallows showed a tendency to shorten after mosapride treatment (P = 0.06). The liquid bolus transit became faster after mosapride, especially in manometrically ineffective liquid swallows (P < 0.01). The total bolus transit time for manometrically normal viscous swallows decreased after pretreatment with mosapride (7.7 seconds; range, 6.8-9.2) in comparison with placebo (8.1 seconds; range, 7.1-...Continue Reading

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Citations

Jan 4, 2008·Journal of Gastroenterology and Hepatology·Kwong Ming FockSathoporn Manatsathit
Nov 1, 2008·Therapeutic Advances in Gastroenterology·Yoshikazu Kinoshita, Shunji Ishihara
May 7, 2008·Drugs·Monique P Curran, Dean M Robinson
Nov 26, 2011·Drugs·Tiberiu Hershcovici, Ronnie Fass
Jun 30, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T HershcoviciR Fass
Feb 24, 2012·Alimentary Pharmacology & Therapeutics·J TackV Stanghellini
Apr 20, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C L ChenW C Orr
Jul 27, 2010·British Journal of Clinical Pharmacology·Yao-Chun HsuHwai-Jeng Lin
Sep 13, 2015·BMC Gastroenterology·Norihisa IshimuraYoshikazu Kinoshita
Nov 17, 2012·Revista de gastroenterología de México·F M Huerta-IgaUNKNOWN el Grupo Mexicano para el Estudio de la Enfermedad por Reflujo Gastroesofágico 2011
Aug 27, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Makoto KomuraTadashi Iwanaka
Jul 3, 2015·United European Gastroenterology Journal·Charlotte ScheerensNathalie Rommel
Mar 22, 2019·The Kaohsiung Journal of Medical Sciences·Wei-Yi LeiChien-Lin Chen
Nov 23, 2011·Nature Reviews. Gastroenterology & Hepatology·Arne Kandulski, Peter Malfertheiner
Oct 9, 2013·Scandinavian Journal of Gastroenterology·Chien-Lin ChenWilliam C Orr
Oct 16, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yasushi FunakiKunio Kasugai
Jun 15, 2021·Frontiers in Pharmacology·Sawangpong JandeeTim Vanuytsel

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