The Effect of Multidomain Lifestyle Intervention on Daily Functioning in Older People

Journal of the American Geriatrics Society
Jenni KulmalaMiia Kivipelto

Abstract

To investigate the effect of a 2-year multidomain lifestyle intervention on daily functioning of older people. A 2-year randomized controlled trial (ClinicalTrials.gov, NCT01041989). Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability. A total of 1260 older adults, with a mean age of 69 years at the baseline, who were at risk of cognitive decline. A multidomain intervention, including simultaneous physical activity intervention, nutritional counseling, vascular risk monitoring and management, and cognitive training and social activity. The ability to perform daily activities (activities of daily living [ADLs] and instrumental ADLs) and physical performance (Short Physical Performance Battery). The mean baseline ADL score was 18.1 (SD = 2.6) points; the scale ranges from 17 (no difficulties) to 85 (total ADL dependence). During the 2-year intervention, the ADL disability score slightly increased in the control group, while in the intervention group, it remained relatively stable. Based on the latent growth curve model, the difference in the change between the intervention and control groups was -0.95 (95% confidence interval [CI] = -1.61 to -0.28) after 1 year and -1.20 (95% CI = -2.02 to -0.38) a...Continue Reading

References

Jan 1, 1994·Social Science & Medicine·L M Verbrugge, A M Jette
Nov 13, 2002·JAMA : the Journal of the American Medical Association·Karlene BallUNKNOWN Advanced Cognitive Training for Independent and Vital Elderly Study Group
Sep 21, 1963·JAMA : the Journal of the American Medical Association·S KATZM W JAFFE
Jul 22, 2004·European Journal of Clinical Nutrition·T J ParsonsC Power
Apr 28, 2007·Scandinavian Journal of Infectious Diseases·Sofia D NybergUNKNOWN The Finnish Study Group For Antimicrobial Resistance
Jun 17, 2008·Science·Erika DahlinLars Nyberg
Oct 26, 2010·Journal of General Internal Medicine·Susan E HardyHoward B Degenholtz
Jun 27, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K BackholerA Peeters
Jan 22, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Miia KivipeltoHilkka Soininen
Mar 26, 2013·Maturitas·Anne Felicia AmbroseJeffrey M Hausdorff
Mar 29, 2014·Geriatrics & Gerontology International·Jenni KulmalaSirpa Hartikainen
May 29, 2014·JAMA : the Journal of the American Medical Association·Marco PahorUNKNOWN LIFE study investigators
Dec 3, 2014·Obesity·Denise K HoustonUNKNOWN Action for Health In Diabetes (Look AHEAD) Movement and Memory Ancillary Study Research Group
Feb 10, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Leslie VaughanSally A Shumaker
Oct 21, 2016·Journal of the American Geriatrics Society·Mini E JacobAnne B Newman
Nov 23, 2016·PloS One·Juliana Lustosa TorresCesar de Oliveira
Feb 9, 2017·Journal of the American Geriatrics Society·Todd M ManiniUNKNOWN LIFE study investigators

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Citations

Aug 19, 2020·Age and Ageing·Laura KolehmainenJenni Kulmala
Jan 30, 2021·PloS One·Cíntia Aparecida Garcia MeneguciJair Sindra Virtuoso Júnior
Mar 20, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Susanne RöhrUNKNOWN World‐Wide FINGERS Study Group
Jun 22, 2021·Journal of Alzheimer's Disease : JAD·Alina SolomonTiia Ngandu
Jul 13, 2021·Frontiers in Aging Neuroscience·Sofia Pereira das NevesMiia Kivipelto
Aug 28, 2021·European Journal of Public Health·Jenni KulmalaMiia Kivipelto
Nov 9, 2021·The Cochrane Database of Systematic Reviews·Melanie HafdiEdo Richard

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