The effect of multistrain probiotic supplementation in two doses on iron metabolism in obese postmenopausal women: a randomized trial

Food & Function
Katarzyna SkrypnikJoanna Suliburska

Abstract

Obesity leads to detrimental abnormalities of iron (Fe) metabolism. So far, studies have shown that single-strain probiotic supplementation ameliorates the gut microbiota quality disrupted in the obese and improves Fe homeostasis. The effect of multistrain probiotic supplementation and its dose-dependence in obese postmenopausal women remain unknown. The study aimed to investigate the effect of multistrain probiotic supplementation in two doses on selected parameters of Fe metabolism in obese postmenopausal female patients. Three groups of obese postmenopausal women, 30 subjects each, received nine-strain oral probiotic supplement at a daily dose of 2.5 × 109 CFU (LD group), 1 × 1010 CFU (HD group), or placebo for 12 weeks (ClinicalTrails.gov no: NCT03100162). After the intervention, the hair Fe content was lower in both supplemented groups compared to the baseline, the serum zinc (Zn) concentration was higher in the LD group and lower in the HD group vs. the baseline, and the serum erythroferrone (FAM) concentration was lower in the HD group and serum ferritin (FE) concentration was higher in the LD group vs. the baseline. In the whole study population after the completion of the intervention hair Zn correlated positively with...Continue Reading

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Citations

Jun 18, 2020·International Journal of Environmental Research and Public Health·Jacek WilczyńskiNatalia Habik-Tatarowska
Jun 20, 2020·FEMS Microbiology Reviews·Francesca De FilippisDanilo Ercolini
Dec 13, 2019·PloS One·Maria Suzana MarquesJosiane Santos Brant Rocha
Feb 23, 2021·Journal of Dietary Supplements·Amanda SandroniDiane M DellaValle
Aug 7, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Karine Scanci da Silva PontesMárcia Regina Simas Torres Klein

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Methods Mentioned

BETA
pharmacotherapy
hormone replacement therapy
enzyme-linked immunosorbent assay
ELISA
flame atomic absorption spectrometry

Clinical Trials Mentioned

NCT03100162

Software Mentioned

Statistica

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