The effect of muscle ageing and sarcopenia on spinal segmental loads

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Dominika IgnasiakStephen J Ferguson

Abstract

The interrelations between age-related muscle deterioration (sarcopenia) and vertebral fractures have been suggested based on clinical observations, but the biomechanical relationships have not been explored. The study aim was to investigate the effects of muscle ageing and sarcopenia on muscle recruitment patterns and spinal loads, using musculoskeletal multi-body modelling. A generic AnyBody model of the thoracolumbar spine, including > 600 fascicles representing trunk musculature, was used. Several stages of normal ageing and sarcopenia were modelled by reduced strength of erector spinae and multifidus muscles (ageing from 3rd to 6th life decade: ≥ 60% of normal strength; sarcopenia: mild 60%, moderate 48%, severe 36%, very severe 24%), reflecting the reported decrease in cross-sectional area and increased fat infiltration. All other model parameters were kept unchanged. Full-range flexion was simulated using inverse dynamics with muscle optimization to predict spinal loads and muscle recruitment patterns. The muscle changes due to normal ageing (≥ 60% strength) had a minor effect on predicted loads and provoked only slightly elevated muscle activities. Severe (36%) and very severe (24%) stages of sarcopenia, however, were a...Continue Reading

References

May 1, 1983·The Journal of Physiology·R J MaughanJ Weir
Aug 18, 1997·The American Journal of Medicine·P D Ross
Mar 2, 1999·Journal of Biomechanics·J CholewickiS M McGill
Oct 20, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L J MeltonB L Riggs
Feb 22, 2001·Journal of Biomechanics·J RasmussenM Voigt
Sep 13, 2003·Journal of Applied Physiology·Timothy J Doherty
Dec 8, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·N Arjmand, A Shirazi-Adl
Jul 5, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Andrew M BriggsKim L Bennell
Aug 12, 2006·Journal of Biomechanics·Mark de ZeeErik B Simonsen
Oct 31, 2006·Clinical Biomechanics·Ahmet ErdemirAntonie J van den Bogert
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Jan 9, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A M BriggsJ D Wark
May 3, 2007·Physical Therapy·Andrew M BriggsKim L Bennell
Jul 9, 2008·Disability and Rehabilitation·Marco V NariciConstantinos N Maganaris
Sep 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T LangT B Harris
Jul 27, 2010·Clinical Biomechanics·Ian A F StokesSharon M Henry
Feb 15, 2011·Biomechanics and Modeling in Mechanobiology·Miguel ChristophyOliver M O'Reilly
Mar 12, 2011·Clinical Biomechanics·Devinder K A SinghRaymond Y W Lee
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Stephan von HaehlingStefan D Anker
Oct 8, 2011·Medical Engineering & Physics·Kap-Soo HanAntonius Rohlmann
Mar 15, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Francesco LandiGraziano Onder
May 17, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alexander G BrunoMary L Bouxsein
Jul 11, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S VerschuerenS Boonen
Sep 15, 2012·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Chia-Hung WuKuo-Chin Huang
Oct 9, 2012·Medical Engineering & Physics·Kap-Soo HanWilliam R Taylor
Oct 28, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Tetsuro HidaAtsushi Harada
Mar 26, 2015·Ageing Research Reviews·Camille TagliaferriVéronique Coxam
Apr 19, 2015·Bone·M H EdwardsC Cooper
Apr 23, 2015·Journal of Biomechanical Engineering·Alexander G BrunoDennis E Anderson
Dec 5, 2015·AJNR. American Journal of Neuroradiology·R J CrawfordE J Ulbrich
Dec 20, 2015·Journal of Biomechanics·Dominika IgnasiakStephen J Ferguson
Apr 5, 2016·Current Osteoporosis Reports·Hossein Mokhtarzadeh, Dennis E Anderson
May 26, 2016·PloS One·Waldo ValenzuelaMauricio Reyes
Jul 29, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Masoud MalakoutianThomas Oxland
Aug 9, 2016·The Spine Journal : Official Journal of the North American Spine Society·Shin Heon LeeYoung Seok Lee

❮ Previous
Next ❯

Citations

Oct 3, 2019·Asian Spine Journal·Ashish AnandShanmuganathan Rajasekaran
Apr 30, 2020·International Journal of Molecular Sciences·Yu-Kai KuoMeng-Huang Wu
Jul 18, 2020·Global Spine Journal·Zachariah W PinterArjun S Sebastian
Jul 28, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Katarzyna Nowakowska-LipiecMarek Gzik
Mar 28, 2019·The Journal of Orthopaedic and Sports Physical Therapy·Rebecca J CrawfordJames M Elliott
Mar 30, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Masoud MalakoutianThomas R Oxland
Apr 4, 2021·Journal of Clinical Medicine·Yu-Ching LinFang-Ping Chen
Sep 6, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tetsuro OhbaHirotaka Haro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Dominika IgnasiakStephen J Ferguson
© 2022 Meta ULC. All rights reserved