The effect of mycophenolic acid on epigenetic modifications in lupus CD4+T cells

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Yang YangQ Lu

Abstract

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease involving multiple organs and characterized by overproduction of autoantibodies and T and B cell abnormalities. The treatment for SLE has been restricted to immunosuppressants and corticosteroids. Mycophenolate mofetil (MMF), as a relatively new immunosuppressant, is now widely used in the treatment of SLE patients, particularly those with nephritis. However, it is unclear whether mycophenolic acid (MPA) could modulate the reported disorders of epigenetic status in CD4(+)T cells from SLE patients. In this study, we demonstrated that MPA can upregulate the histone H3/H4 global acetylation status by regulating HATs and HDACs in lupus CD4(+)T cells. Furthermore, we found that MPA also affected the histone H4 acetylation and histone H3K4 tri-methylation levels in CD40L promoter region that inhibited the expression of CD40L. These findings indicate the potential epigenetic mechanism of therapeutic effects of MPA in SLE.

References

Oct 16, 1999·Science·A P Wolffe, M A Matzke
Jul 6, 2000·Immunopharmacology·A C Allison, E M Eugui
Nov 6, 2003·Journal of Cell Science·Nancy HoggAlison McDowall
Dec 13, 2005·Journal of Proteome Research·Benjamin A GarciaNilamadhab Mishra
Aug 1, 2006·Briefings in Functional Genomics & Proteomics·Loredana VerdoneErnesto Di Mauro
Nov 15, 2006·Current Drug Targets·Johannes Trapp, Manfred Jung
Dec 23, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Yujun Pan, Amr H Sawalha
Jun 13, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ying ZhouQianjin Lu
Jul 15, 2009·Seminars in Immunology·Anna L PetersGail A Bishop
Dec 21, 2011·International Journal of Clinical Rheumatology·Matlock A Jeffries, Amr H Sawalha
Aug 2, 2013·European Journal of Clinical Investigation·Eleni A FrangouDimitrios T Boumpas
Aug 15, 2013·Current Rheumatology Reports·Patrícia Costa-Reis, Kathleen E Sullivan
Aug 24, 2013·Arthritis Research & Therapy·Fabien B VincentEric F Morand
Oct 17, 2013·Autoimmunity·Aijing Liu, Antonio La Cava
Apr 8, 2014·Néphrologie & thérapeutique·Noémie Jourde-ChicheUNKNOWN Groupe Coopératif sur le Lupus Rénal

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Citations

Mar 18, 2016·Journal of Autoimmunity·Ming ZhaoQianjin Lu
Nov 2, 2016·Clinical and Experimental Immunology·S H ChenB Sun
Nov 26, 2016·Epigenomics·Christian M HedrichGeorge C Tsokos
Nov 23, 2016·Nature Reviews. Rheumatology·George C TsokosKathleen E Sullivan
May 31, 2019·Current Opinion in Rheumatology·Amandine Charras, Christian M Hedrich
Oct 28, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sigrun R HofmannChristian M Hedrich
Feb 6, 2020·Autoimmunity·Carolina HurtadoGloria Vásquez
Feb 20, 2016·Biomedical Reports·Gong Xiao, Xiaoxia Zuo
Dec 13, 2018·Nature Reviews. Rheumatology·Mariele GattoAndrea Doria
Aug 9, 2017·Clinical Epigenetics·Zijun WangQianjin Lu
Feb 15, 2020·Nature Reviews. Rheumatology·Jasper C A Broen, Jacob M van Laar
Jul 29, 2017·Current Rheumatology Reports·Christian Michael Hedrich
Mar 7, 2021·La Revue de médecine interne·G VialP Duffau
May 28, 2021·Frontiers in Cell and Developmental Biology·Fabian Vega-TapiaLoreto Cuitino
Dec 12, 2017·Best Practice & Research. Clinical Rheumatology·Thomas Rose, Thomas Dörner

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