The effect of NAD-299 and TCB-2 on learning and memory, hippocampal BDNF levels and amyloid plaques in Streptozotocin-induced memory deficits in male rats

Psychopharmacology
Simin AfsharSara Soleimani Asl

Abstract

Alzheimer's disease (AD) is the most common form of dementia characterized by a progressive decline in cognitive function. The serotonergic system via the 5-HT1A receptor and 5-HT2A receptor is proposed to affect the cognitive process. In the present study, the effects of NAD-299 (5-HT1AR antagonist) and TCB-2 (5-HT2AR agonist) on learning and memory processes, hippocampal brain-derived neurotrophic factor (BDNF) levels, neuronal necrosis, and Aβ plaque production have been investigated on the intracerebroventricular (icv) injection of streptozotocin (STZ)-induced memory deficits in rats. Fifty-four adult male Wistar rats (250-300 g) were divided into six groups (n = 9 in each group): control, sham-operated, AD (icv-STZ (3 mg/kg, 10 μl)), AD+NAD-299 (5 μg/1 μl icv for 30 days), AD+TCB-2 (5 μg/1 μl icv for 30 days), and AD+NAD-299 + TCB-2 (NAD-299 (5 μg/0.5 μl icv) and TCB-2 (5 μg/0.5 μl icv) for 30 days). Following the treatment period, rats were subjected to behavioral tests of learning and memory. Then, hippocampal BDNF, amyloid-beta (Aβ) plaque, and neuronal loss were determined by ELISA Kit, Congo red staining, and Nissl staining, respectively. The results of behavioral tests showed that icv-STZ injection decreased the disc...Continue Reading

References

Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Jul 25, 1995·European Journal of Pharmacology·E A ForsterA Fletcher
Dec 5, 1997·Brain Research. Molecular Brain Research·B ConnorM Dragunow
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Sep 14, 1999·British Journal of Pharmacology·J R RaymondM N Garnovskaya
Jan 4, 2001·Trends in Neurosciences·A F Schinder, M Poo
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ilga Misane, Sven Ove Ogren
Dec 9, 2003·Trends in Molecular Medicine·Diethelm W RichterEvgeni Ponimaskin
Mar 17, 2004·Current Opinion in Pharmacology·Eero Castrén
Apr 9, 2005·Behavioural Brain Research·Nikolaos PitsikasNikolaos Sakellaridis
Apr 15, 2005·Neuropharmacology·Maria LüttgenSven Ove Ogren
Oct 15, 2005·The Journal of Pharmacology and Experimental Therapeutics·Nather MadjidSven Ove Ogren
Jan 9, 2007·Biochimica Et Biophysica Acta·M NewmanM Lardelli
May 9, 2007·Medicine, Health Care, and Philosophy·Wim Dekkers, Marcel Olde Rikkert
Jun 5, 2007·Neurobiology of Aging·S G HasselbalchG M Knudsen
Aug 10, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rita R Romito-DiGiacomoKarl Herrup
Aug 19, 2008·Brain Research Reviews·Lucia Tapia-ArancibiaSandor Arancibia
Jun 30, 2009·Pharmacotherapy·Aaron M CookJimmi Hatton
Oct 14, 2009·Psychopharmacology·Meredith A FoxDennis L Murphy
Feb 23, 2010·Pharmacology, Biochemistry, and Behavior·Miguel SkirzewskiPedro Rada
Apr 24, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jan KehrSven Ove Ogren
Oct 12, 2010·Critical Reviews in Biochemistry and Molecular Biology·Laura M Bohn, Cullen L Schmid
May 3, 2011·Journal of Neural Transmission·Melita Salkovic-PetrisicPeter Riederer
Jul 12, 2011·Journal of Alzheimer's Disease : JAD·Kevin H ChenJagadeesh S Rao
Dec 31, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Parisa Hasanein, Siamak Shahidi
May 26, 2012·TheScientificWorldJournal·Laura Cristina BerumenGuadalupe García-Alcocer
Oct 27, 2012·Biogerontology·Sara FidalgoShona H Wood
May 29, 2013·Journal of Visualized Experiments : JoVE·Sarah L DeVos, Timothy M Miller

❮ Previous
Next ❯

Citations

Nov 16, 2018·The International Journal of Neuroscience·Bita BeigiNasrin Hashemi-Firouzi
Jul 23, 2019·Medicinal Research Reviews·Lili ZhangRongbiao Pi
Mar 19, 2020·International Journal of Molecular Sciences·Cristiano BombardiGiuseppe Di Giovanni
Oct 24, 2020·Neurochemical Research·Anton S TsybkoVladimir S Naumenko
May 1, 2021·Journal of Clinical Medicine·Masahiro ToKeiichi Tsukinoki
Jul 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Shinichiro OchiShu-Ichi Ueno

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

GraphPad

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.