The effect of nanoparticle permeation on the bulk rheological properties of mucus from the small intestine

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Matthew D WilcoxJ P Pearson

Abstract

The effectiveness of delivering oral therapeutic peptides, proteins and nucleotides is often hindered by the protective mucus barrier that covers mucosal surfaces of the gastrointestinal (GI) tract. Encapsulation of active pharmaceutical ingredients (API) in nanocarriers is a potential strategy to protect the cargo but they still have to pass the mucus barrier. Decorating nanoparticles with proteolytic enzymes has been shown to increase the permeation through mucus. Here we investigate the effect of poly(acrylic acid) (PAA) nanoparticles decorated with bromelain (BRO), a proteolytic enzyme from pineapple stem, on the bulk rheology of mucus as well as non-decorated poly(lactic-co-glycolic acid) (PLGA) nanoparticles. Porcine intestinal mucus from the small intestine was incubated for 30min in the presence of PLGA nanoparticles or polyacrylic nanoparticles decorated with bromelain (PAA-BRO). The effect of nanoparticles on the rheological properties, weight of gel, released glycoprotein content from mucus as well as the viscosity of liquid removed was assessed. Treatment with nanoparticles decreased mucus gel strength with PAA-BRO reducing it the most. PAA-BRO nanoparticles resulted in the release of increased glycoprotein from the...Continue Reading

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Citations

Nov 26, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Julia RohrerAndreas Bernkop-Schnürch
Sep 30, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Mar 25, 2016·Therapeutic Delivery·Jeffrey P PearsonMatthew D Wilcox
Apr 9, 2016·Advanced Drug Delivery Reviews·Hélène MalhaireFrédéric Lagarce
Jun 14, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abhijit A DateLaura M Ensign
Jul 14, 2018·NPJ Biofilms and Microbiomes·Cassie R BakshaniJ Grant Burgess
Jan 3, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gustavo Ruiz-Pulido, Dora I Medina
May 30, 2017·Advances in Colloid and Interface Science·David Julian McClementsPhilip Demokritou
Mar 2, 2021·International Journal of Pharmaceutics·Liu LiuXiaoqin Chu
Apr 7, 2018·Advances in Colloid and Interface Science·Janaína Artem AtaideEliana B Souto

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