The effect of Nd:YAG laser membranotomy and intravitreal tissue plasminogen activator with gas on massive diabetic premacular hemorrhage

Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye
Jin ChungYoung-Chun Lee

Abstract

To investigate the combined therapeutic effects of Nd:YAG laser membranotomy and intravitreal tissue plasminogen activator (tPA) (Actilyse; Boehringer Ingelheim, Ingelheim, Germany) injection with perfluoropropane (C3F8, 100%) injection on massive diabetic premacular hemorrhage. Nd:YAG laser membranotomy was performed on the hemorrhagic membrane of premacular hemorrhage, and tPA (25 microg/0.1 mL) was injected into the vitreous cavity of seven eyes with massive diabetic premacular hemorrhage. For each procedure 0.2 mL of C3F8 was also injected. After the combined therapy, the patients recovered vision within 4 weeks and the hemorrhages were completely absorbed within 8 weeks. Visual acuity at the last follow-up visit improved to a mean of 10 logarithm of the minimum angle of resolution lines in all cases. There were no associated ophthalmic complications. The combined therapy resulted in resolution of premacular hemorrhages with proliferative diabetic retinopathy and may allow for faster resolution of premacular hemorrhages and lessen the need for vitrectomy.

References

Feb 15, 1991·American Journal of Ophthalmology·H LewisB R Straatsma
Feb 1, 1990·Archives of Ophthalmology·M W JohnsonR N Johnson
Oct 15, 1990·American Journal of Ophthalmology·C K DabbsA R Ward
Dec 1, 1986·Ophthalmology·J T ThompsonB M Glaser
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M J TassignonL Van Mulders
Jan 15, 1989·American Journal of Ophthalmology·V P GabelC A Puliafito
Aug 1, 1988·Archives of Ophthalmology·G A WilliamsG W Abrams
Mar 1, 1986·Ophthalmology·R C RamsayH L Cantrill
Jun 1, 1993·Archives of Ophthalmology·T C VerstraetenG A Williams
Sep 25, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Stephan D Schulze, Lutz Hesse
Dec 23, 2003·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Detlef Holland, Burkhard Wiechens

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Citations

Apr 1, 2011·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Abdulrahman A Alghadyan
May 21, 2014·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Oscar KuruvillaMichael D Ober

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