The effect of nebulized albuterol on the activity of the renin-angiotensin system in asthma

Chest
E A MillarN C Thomson

Abstract

We have previously described activation of the renin-angiotensin system (RAS) in acute severe asthma and have also reported activation of the RAS in normal subjects by single doses of nebulized beta 2-agonists. In the present study, we have examined the effect of single and multiple doses of nebulized albuterol on the activity of the RAS in mild asthma. Eight patients with mild asthma were studied. The effect of single and multiple doses of nebulized albuterol (5 mg) on the activity of the RAS was compared with that of placebo using a randomized, double-blind crossover study design. Nebulized drugs were administered at time 0 and 30 min. Plasma renin, angiotensin II (Ang II), and serum potassium levels were measured at baseline following a short rest, and thereafter at intervals up to 150 min. Renin levels increased after both the single (S) and double (D) nebulized doses of albuterol and were significantly greater than placebo at 30 min after S, and at 45 and 120 min after D. Plasma Ang II level also increased after S and D and was significantly greater than placebo at 30 and 45 min after S, and at 30 min and all timepoints thereafter following D. In addition, the effect of D was significantly greater than S at 45 min. These r...Continue Reading

References

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Citations

Jul 17, 2003·The Journal of Emergency Medicine·Diana PancuJames Reed
Sep 3, 2011·American Journal of Respiratory and Critical Care Medicine·Gavin D Perkins, Daniel F McAuley
Aug 9, 2013·Centaurus; International Magazine of the History of Science and Medicine·Elaine Leong

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