The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy

Endocrinology
Mark H VickersM Harris

Abstract

An adverse prenatal environment may induce long-term metabolic consequences, in particular obesity, hyperleptinemia, insulin resistance, and type 2 diabetes. Although the mechanisms are unclear, this "programming" has generally been considered an irreversible change in developmental trajectory. Adult offspring of rats subjected to undernutrition (UN) during pregnancy develop obesity, hyperinsulinemia, and hyperleptinemia, especially in the presence of a high-fat diet. Using this model of maternal UN, we have recently shown that neonatal leptin treatment in females reverses the postnatal sequelae induced by developmental programming. To examine possible gender-related effects of neonatal leptin treatment, the present study investigated the effect of neonatal leptin treatment on the metabolic phenotype of adult male offspring. Leptin treatment (recombinant rat leptin, 2.5 microg/g.d, sc) from postnatal d 3-13 resulted in a transient slowing of neonatal weight gain, particularly in programmed offspring. Neonatal leptin treatment of male offspring from normally nourished mothers caused an increase in diet-induced weight gain and related metabolic sequelae, including hyperinsulinemia and increased total body adiposity compared with ...Continue Reading

References

Jan 1, 1992·Experimental and Clinical Endocrinology·A PlagemannG Dörner
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A Hamann, S Matthaei
Sep 23, 1997·Biochemical and Biophysical Research Communications·A L PallettV Emilsson
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·N HoggardJ G Mercer
Dec 17, 1997·Biochemical and Biophysical Research Communications·K L HouseknechtK Beerman
Nov 24, 1999·Frontiers in Neuroendocrinology·F F Casanueva, C Dieguez
Jan 25, 2000·American Journal of Physiology. Endocrinology and Metabolism·T J Kieffer, J F Habener
Jun 9, 2000·Annual Review of Physiology·R S Ahima, J S Flier
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·M H VickersP D Gluckman
Nov 28, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M S IslamV Emilsson
Jan 26, 2002·British Medical Bulletin·C N Hales, D J Barker
Jan 26, 2002·British Medical Bulletin·S E Ozanne
Aug 22, 2002·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C de Oliveira CravoC Ramos
Nov 7, 2002·Cell·Shu TakedaGerard Karsenty
Feb 8, 2003·Science·Jean Marx
Jun 5, 2003·Physiology & Behavior·Ruth B S HarrisTiffany D Mitchell
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M H VickersP D Gluckman
Nov 15, 2003·Molecular and Cellular Endocrinology·Barbara A MorashMichael Wilkinson
Mar 27, 2004·Endocrinology·Sebastien G Bouret, Richard B Simerly
Apr 6, 2004·Science·Sebastien G BouretRichard B Simerly
Apr 6, 2004·Science·Shirly PintoTamas L Horvath
Jul 9, 2004·Pediatric Research·Peter D Gluckman, Mark A Hanson
Aug 31, 2004·The Journal of Nutrition·Paul Cohen, Jeffrey M Friedman
Sep 18, 2004·Science·Peter D Gluckman, Mark A Hanson
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Germán IñiguezVerónica Mericq
Feb 12, 2005·The Journal of Physiology·I Caroline McMillenBeverly S Mühlhäusler
Jul 16, 2005·Endocrinology·M H VickersM Harris
Jan 7, 2006·Nature Medicine·Tamas L Horvath, Jens C Bruning
Mar 29, 2006·Diabetes·Deborah J CleggStephen C Benoit
Mar 31, 2006·The British Journal of Nutrition·Fabiane Pereira TosteMagna Cottini Fonseca Passos
May 2, 2006·The Journal of Endocrinology·Stefan O KrechowecBernhard H Breier
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Barry E Levin
Dec 16, 2006·Experimental Physiology·P D Taylor, L Poston

❮ Previous
Next ❯

Citations

Jul 11, 2009·Journal of Physiology and Biochemistry·F I MilagroJ A Martínez
Nov 8, 2013·Internal and Emergency Medicine·Giovanni Di Minno, Giovanni de Gaetano
Aug 6, 2008·The British Journal of Nutrition·Magna Cottini Fonseca PassosEgberto Gaspar de Moura
Aug 6, 2008·The British Journal of Nutrition·Andreas Plagemann, Thomas Harder
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P D Gluckman, M A Hanson
Mar 1, 2011·Acta Physiologica·H ItohUNKNOWN Hamamatsu Birth Cohort for Mothers and Children (HBC) Study Team
Feb 27, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christy L WhiteChristopher D Morrison
Oct 16, 2012·The Journal of Clinical Investigation·Esther Fuente-MartínJulie A Chowen
Apr 12, 2013·The Journal of Endocrinology·Charlotte BenoitMohammed Taouis
Sep 30, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·S P SébertM E Symonds
Dec 6, 2012·ISRN Pediatrics·Claudia Eberle, Christoph Ament
Mar 26, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P T KatzmarzykJ A Yanovski
Dec 26, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Altankhuu TungalagsuvdMinoru Irahara
Feb 4, 2009·The Journal of Physiology·Alison J Forhead, Abigail L Fowden
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·M H Vickers, D M Sloboda
Sep 29, 2011·Drug Discovery Today·Man Chen, Lubo Zhang
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Lucilla Poston
Sep 4, 2009·Psychoneuroendocrinology·Cristina García-CáceresJulie A Chowen
Jul 1, 2008·Physiology & Behavior·Floor RemmersHenriette A Delemarre-van de Waal
Jul 25, 2015·Frontiers in Neuroendocrinology·Lori M Zeltser
Mar 1, 2009·Journal of Diabetes·Ricardo Vinícius Ledesma ContartezeEliete Luciano
Feb 15, 2013·Obesity·Caroline E BoekeMatthew W Gillman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

© 2021 Meta ULC. All rights reserved