Jan 1, 1976

The effect of neonatal rat graft-vs-host disease (GVHD) on Fc receptor lymphocytes

The Journal of Immunology : Official Journal of the American Association of Immunologists
J ClancyC E Boettcher


The level of Fc receptor rosette-forming lymphocytes (Fc-RFL) was examined in spleen and lymph node cell suspension from neonatal DA and BN rats inoculated within 24 hr of birth with either allogeneic L (experimental) or syngeneic (control) lymphoid cells. In addition, these levels were compared to fetal and neonatal animals that received no injection. The indicator cells (EA) were sheep erythrocytes sensitized with one-half concentration of the highest dilution of rabbit anti-sheep erythrocyte IgG(A) which agglutinated an equal amount of 1% suspension of E. Care was taken to exclude scoring macrophages by injecting colloidal carbon at least 1 hr before killing the test animals. The spleen of 19-day DA fetal rats exhibited a level of 19.3% Fc-RFL, similar to that of animals having received adult syngeneic cells at birth (40.0%) by day 7. Thereafter the level of Fc-RFL did not vary appreciably between these two groups. However, as early as 2 days after inoculation there was a significantly greater number of Fc-RFL in the spleen of experimental DA neonates compared to controls. The lymph nodes of experimental animals did not exhibit a significantly greater number of Fc-RFL until day 6 with both tissue compartments peaking at day ...Continue Reading

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Mentioned in this Paper

Fetal Structures
Graft-vs-Host Disease
August Rats
Lymphoid Cells
Graft Vs Host Reaction
Receptors, Drug
Rats, Inbred BN
Lymph Nodes
Rats, Inbred Lew

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