PMID: 6889217Jan 1, 1983Paper

The effect of nifedipine on arterial pressure and reflex cardiac control

Postgraduate Medical Journal
W A LittlerR A McLeay


Nine patients with untreated, essential hypertension (mean casual blood pressure 173/109 +/- 14/7 mmHg (+/- s.d.] were studied in the control state and then following 16 weeks treatment with nifedipine 10 mg orally 8 hourly. Direct arterial blood pressure was monitored continuously over 24 hours and demonstrated that nifedipine significantly reduced systolic and diastolic blood pressure throughout the day and the night. The variability of blood pressure was not altered by nifedipine therapy. There was no significant change in heart rate after nifedipine therapy. At each study the sensitivity and setting of the baroreflex response to intravenous phenylephrine was measured. Following chronic nifedipine therapy there was re-setting of the sino-aortic baroreflex and an increase in its sensitivity.


May 21, 1979·European Journal of Clinical Pharmacology·O L PedersenE B Pedersen
Dec 18, 1978·European Journal of Clinical Pharmacology·O L Pedersen, E Mikkelsen
May 1, 1982·Lancet·R B DevereuxJ H Laragh


Jan 1, 1990·European Journal of Clinical Pharmacology·N BacrachevaN Rietbrock
Jan 1, 1984·European Journal of Clinical Pharmacology·J F GiudicelliA Jacolot
Jan 1, 1985·European Journal of Clinical Pharmacology·P CoruzziA Novarini
Jan 1, 1985·European Journal of Clinical Pharmacology·P J MaceW A Littler
Jan 1, 1986·European Journal of Clinical Pharmacology·J R M'Buyamba-KabanguA Amery
Oct 1, 1987·American Heart Journal·B N Prichard, B Tomlinson
Jul 17, 1985·European Journal of Pharmacology·H M NievelsteinH A Struyker Boudier
Mar 3, 1984·Lancet·L H Opie
Feb 1, 1986·Journal of the American College of Cardiology·W KiowskiF R Bühler
Apr 27, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·T DimoS V Rakotonirina
Mar 1, 1990·British Journal of Clinical Pharmacology·P ThomasD J Sheridan
May 1, 1987·Clinical and Experimental Pharmacology & Physiology·J Staszewska-Woolley
Apr 1, 1988·Clinical and Experimental Pharmacology & Physiology·S A Smith, W A Littler
Jan 1, 1989·Fundamental & Clinical Pharmacology·A Berdeaux
Oct 5, 1984·The American Journal of Medicine·B M MassieJ F Tubau
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·M BursztynT Rosenthal
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·R G AsmarM E Safar
Oct 1, 1987·American Heart Journal·F M Fouad-Tarazi
Jun 1, 1984·The American Journal of Cardiology·I K InouyeD Loge
Oct 11, 1985·The American Journal of Medicine·R C DavidsonD K Stewart
Dec 21, 1987·The American Journal of Medicine·I GavrasB Garrett
Jan 25, 1985·The American Journal of Cardiology·B F Robinson
Jan 23, 1987·The American Journal of Cardiology·J H Bauer, G Reams
Jan 23, 1987·The American Journal of Cardiology·M Moser
Jul 1, 1988·Clinical Cardiology·S G ChrysantA Hitchcock
Jan 1, 1985·British Journal of Clinical Pharmacology·W A Littler, M A Young
Jan 1, 1985·British Journal of Clinical Pharmacology·M A YoungW A Littler
Jan 1, 1987·Fundamental & Clinical Pharmacology·A Berdeaux, J F Giudicelli
Sep 1, 1985·Journal of Clinical Pharmacology·I Gavras, H Gavras
Jan 1, 1988·Annals of the New York Academy of Sciences·F R Bühler, W Kiowski
Apr 1, 1989·European Journal of Vascular Surgery·P LewisJ P Woodcock
Feb 1, 1986·American Heart Journal·A K Halperin, L X Cubeddu
Dec 15, 1986·The American Journal of Medicine·J P PachecoR L Reeves
Feb 26, 1986·The American Journal of Cardiology·R G McAllisterS R Hamann
Nov 1, 2001·Journal of Human Hypertension·E O'BrienAnglo-Scandinavian Cardiac Outcomes Trial

Related Concepts

Diastolic Blood Pressure
Pulse Rate
Hypertensive Disease
Reflex Action

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.