PMID: 433608Mar 1, 1979Paper

The effect of nifedipine on the monophasic action potential and refractoriness of the right ventricle of the dog heart in situ after beta-adrenergic receptor blockade

Acta Pharmacologica Et Toxicologica
J P AmlieK Landmark


The effect of nifedipine, a calcium-antagonistic drug, was studied on the electrophysiology of the right ventricle in the dog heart in situ. Monophasic action potential recordings were obtained by the suction electrode technique and refractoriness was measured by means of programmed electrical stimulation. Pentobarbital anaesthesia was used. As the basic cardiac effects of nifedipine can be altered by the release of catecholamines from sympathetic nerves of the heart and vessels, the dogs were pretreated with the beta-adrenergic receptor blocking agent acebutolol which increased the action potential duration and the refractoriness. Intravenous injection of nifedipine 30 microgram/kg body weight decreased the times for 50 and 90 per cent repolarization of the monophasic action potential and to a smaller extent the effective and functional refractory period. It is suggested that nifedipine decreases the action potential duration and the refractoriness of the right ventricle of the dog heart in situ due to a direct effect of the drug on the myocardium.


Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·R BayerR Hennekes
Apr 1, 1976·Acta Pharmacologica Et Toxicologica·H RefsumK Landmark
Aug 1, 1968·Circulation·R ShabetaiW Hammill
Jan 1, 1969·Pflügers Archiv : European journal of physiology·E Carmeliet, J Vereecke
Sep 1, 1971·Circulation Research·A Fabiato, F Fabiato
Mar 1, 1970·The Journal of Physiology·G W Beeler, H Reuter
Jan 1, 1969·Pflügers Archiv : European journal of physiology·D Mascher, K Peper
Aug 27, 1966·Nature·A P Paes de CarvalhoW B Langan
Jun 1, 1959·The American Journal of Physiology·B F HOFFMANH C HERRLICH

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Nov 15, 2011·British Journal of Pharmacology·Herbert M HimmelErich Wettwer

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