PMID: 9170859May 1, 1997Paper

The effect of nitric oxide synthase inhibitor on reperfusion injury to the brain under hypothermic circulatory arrest

[Zasshi] [Journal]
D SegawaS Tanaka

Abstract

The effect of nitric oxide synthase inhibitor-NG-nitro-L-argine methyl ester (L-NAME)-on reperfusion injury of the brain under deep hypothermic circulatory arrest was experimentally investigated in sixteen piglets weighing about 30 kg. Cardiopulmonary bypass was established and animals were cooled to a brain temperature of 20 degrees C and circulatory arrest was performed for 60 minutes followed by reperfusion of 120 minutes. The value of nitric oxide (NO) within the brain was measured with a needle electrode which was inserted into the brain. In the treatment group L-NAME was administered with a intravenous injection of 1.5 mg/kg at the beginning of the reperfusion followed by a 60-minute continuous venous infusion of 1.5 mg/kg/hour. In the control group the value of NO after 120 minutes reperfusion increased significantly compared with pre-circulatory arrest, but in the treatment group it did not. There was significant difference between the groups regarding the NO value after 120 minutes reperfusion. Blood pressure after 120 minutes reperfusion in the treatment group was a little higher than the control group, but there was no significant difference between the groups regarding cerebral blood flow, excess lactate and cerebra...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.