PMID: 6407412Jun 1, 1983Paper

The effect of nitroglycerin cardioplegia on myocardial cooling in patients undergoing myocardial revascularization

The Annals of Thoracic Surgery
R LandymoreA Culliford

Abstract

The effect of intracoronary administration of nitroglycerin on the distribution of cardioplegia and myocardial cooling was assessed in 45 patients undergoing elective myocardial revascularization. The patients were divided into three groups. Myocardial temperature was measured over the right and left coronary artery distributions in Group 1 after the infusion of 1 liter of potassium blood cardioplegic solution (20 mEq of potassium per liter). Similar temperature measurements were made in Group 2 after the addition of 300 micrograms of nitroglycerin to the cardioplegic solution and in Group 3 after the addition of 1,000 micrograms of nitroglycerin. Nitroglycerin did not affect myocardial cooling, and large temperature gradients persisted after delivery of cardioplegia in patients with occlusive coronary artery disease. Unexpectedly, however, the rate of cardioplegia delivery increased by 134%, within the same range of infusion pressures, in patients receiving nitroglycerin. Although nitroglycerin cardioplegia does not affect the regional disparity in the distribution of cardioplegia in patients with severe coronary artery disease, intracoronary administration of nitroglycerin reduces the time required for administration of cardi...Continue Reading

References

Jan 1, 1975·Circulation·J H McAnultyS H Rahimtoola
May 1, 1968·Circulation Research·W M Fam, M McGregor
Nov 1, 1963·American Heart Journal·P F SALISBURYP A RIEBEN

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Citations

Jan 1, 1988·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·E DoneganiM Morea
Oct 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·K BaxterP Jablonski
Jul 1, 1984·The Annals of Thoracic Surgery·A J RobertsJ A Alexander

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