PMID: 3773516Sep 1, 1986Paper

The effect of nivazol and cortivazol, novel synthetic steroids containing a phenylpyrazolo A-ring substitution, on blood pressure in sheep

Journal of Steroid Biochemistry
C D SpenceB A Scoggins

Abstract

This study investigated the effect of 5 day infusions of two structurally novel synthetic steroids, nivazol and cortivazol on blood pressure and in vivo indices of "glucocorticoid" and "mineralocorticoid" activity. Cortivazol at 24 mg/day raised mean arterial pressure (MAP) by 16 mmHg (P less than 0.001). This was associated with increased cardiac rate, and increased fasting plasma [glucose], polyuria and polydipsia a trilogy characteristic of glucocorticoid effect. Cortivazol had no consistent action on plasma [Na] or [K], but caused an initial transient urinary Na retention and raised urinary excretion of Na and K on days 3 and 4 of treatment. Nivazol at 24 mg/day raised MAP 10 mmHg (P less than 0.001), but cardiac rate was unchanged. This infusion was also associated with the glucocorticoid effects of increased fasting plasma [glucose] and increased urine volume. Plasma [K] fell from a control of 4.4 +/- 0.1 to 4.0 +/- 0.1 mmol/l (P less than 0.01) after 5 days of infusion. There was no significant effect of nivazol on urinary Na or K excretion. This study demonstrates that replacement of the 3-keto group, by a bulky phenylpyrazolo group fused to the A ring at position 2 and 3, does not diminish either pressor or glucocortic...Continue Reading

References

Feb 14, 1979·Biochemical and Biophysical Research Communications·S S SimonsD F Johnson
Jan 1, 1979·Clinical and Experimental Hypertension : CHE·J A WhitworthB A Scoggins

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Citations

Oct 1, 1987·Journal of Steroid Biochemistry·C D SpenceB A Scoggins
Jun 17, 2004·Current Opinion in Nephrology and Hypertension·Felix J FreyBrigitte M Frey
Jun 3, 2010·Clinical Science·Piotr SobieszczykJoshua A Beckman

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