The effect of normal saline on renal function and electrolytes in women with preeclampsia.

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Casey S YuleDavid B Nelson

Abstract

Due to a nationwide shortage of Ringer's lactate, normal saline became the intravenous fluid of choice at our institution in May 2018. Recent studies have shown that the administration of normal saline in critically ill patients may have adverse renal effects. Our objective was to evaluate the renal function effects; if any, of normal saline administered to women with preeclampsia receiving magnesium sulfate. This is a prospective observational study of women identified with preeclampsia with severe features, requiring magnesium sulfate prophylaxis. The amount of normal saline administered was calculated and a basic metabolic panel was surveyed 12 h after initiation of magnesium sulfate prophylaxis. Laboratory analytes were examined according to the volume of intravenous normal saline received, including a comparison to those women who did not receive normal saline, to determine the impact of parameters after 12 h of magnesium sulfate prophylaxis. From May 2018 to November 2018, a total of 233 patients receiving magnesium sulfate were identified, 184 of which had received intravenous normal saline. No differences were identified at 12 h in serum chloride or creatinine between those patients who received intravenous normal salin...Continue Reading

References

Jul 1, 1984·American Heart Journal·L T Iseri, J H French
Jul 12, 2016·Obstetrics and Gynecology·Jamie L MorganF Gary Cunningham
Jul 18, 2017·Seminars in Nephrology·Belinda Jim, Vesna D Garovic
Feb 28, 2018·The New England Journal of Medicine·Matthew W SemlerUNKNOWN SMART Investigators and the Pragmatic Critical Care Research Group
Feb 28, 2018·The New England Journal of Medicine·Wesley H SelfUNKNOWN SALT-ED Investigators
Nov 23, 2018·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Maryann Mazer-AmirshahiJohn N van den Anker

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