PMID: 698238Sep 28, 1978Paper

The effect of nutritional state on the lipoprotein lipase activity of isolated fat cells

Biochimica Et Biophysica Acta
I M SpencerD S Robinson

Abstract

The lipoprotein lipase activity of rat epididymal adipose tissue falls on starvation and increases on refeeding. Studies with fat cells isolated from this tissue have shown that increases in the activity of the enzyme occur under appropriate incubation conditions in vitro. The present study compares the responses of cells isolated from the adipose tissue of fed and 48-h starved rats. Fat cells from rats starved for 48 h display a lower initial lipoprotein lipase activity than cells from fed rats. When cells from rats in both nutritional states are incubated in a suitable medium at 25 degrees C, there is a progressive increase in the medium lipoprotein lipase activity. The absolute increase in the total activity of the incubation system during incubations of cells from 48-h starved rats is significantly less than during incubations of cells from fed rats. However, when expressed as a percentage of the initial cell activity, the rises in total activity are similar in the two nutritional states. Cycloheximide has no significant effect on the increase in activity of lipoprotein lipase that occurs with cells from 48-h starved rats. However, it does partially block the increase in activity seen with cells from fed rats and in a manne...Continue Reading

References

Feb 1, 1975·The Biochemical Journal·A CryerD S Robinson
Feb 1, 1968·The Biochemical Journal·D R Wing, D S Robinson
Apr 1, 1973·The Biochemical Journal·A CryerD S Robinson
May 16, 1967·Biochimica Et Biophysica Acta·N PokrajacI L Chaikoff

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Citations

Oct 1, 1987·Journal of Steroid Biochemistry·A ValetteJ Boyer
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·E CoiffierJ Lecerf
Jan 1, 1981·The International Journal of Biochemistry·A Cryer
Oct 1, 1990·Clinical Biochemistry·G Ailhaud
Sep 21, 2010·Metabolism: Clinical and Experimental·Katarzyna SzkudelskaTomasz Szkudelski
Sep 13, 2005·Regulatory Peptides·Takuo NambuKazuwa Nakao
Jul 1, 1987·Cell Biochemistry and Function·A Verine, J Boyer
Jan 19, 2008·Journal of Nutritional Science and Vitaminology·Takahiro Tsujita, Takeshi Takaku
Sep 4, 1987·Biochimica Et Biophysica Acta·H Semb, T Olivecrona

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