The effect of omega-3 fatty-acid supplements on perioperative bleeding following posterior spinal arthrodesis.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Dennis S MeredithFrank P Cammisa

Abstract

To investigate the effect of omega-3 fatty-acid supplements (n-3FA) on bleeding during posterior spinal arthrodesis. We reviewed all one- or two-level posterolateral lumbar decompression/fusions with or without interbody fusion by five surgeons within 3 years. Patients taking n-3FA preoperatively were matched 1:2 with controls based on procedure, surgeon and operative time. Patients with abnormal coagulation parameters, known bleeding disorders or other medications that could affect surgical blood loss were excluded. Twenty-eight patients met inclusion criteria. The n-3FA and control groups were similar with respect to gender, age, body mass index, operative time, and preoperative use of non-steroidal anti-inflammatory drugs. The n-3FAs were stopped an average of 5.2 days before surgery (range 1-10). Mean estimated blood loss (EBL) was 697 ml in the n-3FA group and 771 ml in the control group (p = 0.36). Mean transfused volume of Cell Saver (CS) was 282 ml in the n-3FA group and 321 ml in the control group (p = 0.30). A post hoc power analysis showed that the study was powered to detect a minimum difference of 105 ml for EBL and 50 ml for CS. The multivariate generalized estimating equation did not show a significant difference...Continue Reading

References

Jul 1, 1988·Seminars in Thrombosis and Hemostasis·S H Goodnight
Dec 1, 1985·The Journal of Clinical Investigation·C von Schacky, P C Weber
Jan 1, 1996·The American Journal of Cardiology·J EritslandM Abdelnoor
May 1, 1997·The American Journal of Clinical Nutrition·H R Knapp
May 17, 2005·Journal of the American College of Cardiology·Leonardo CalòMassimo Santini
Mar 21, 2007·The American Journal of Cardiology·Harold E Bays
Feb 2, 2010·Journal of the American College of Cardiology·Eli I LevRan Kornowski
Mar 23, 2011·Journal of Spinal Disorders & Techniques·Christopher K KeplerAmit K Sharma

❮ Previous
Next ❯

Citations

Aug 1, 2015·Cancer Metastasis Reviews·Seyed Fazel NabaviSeyed Mohammad Nabavi
Dec 19, 2013·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·David C EvansChristopher M Jones
Dec 21, 2018·Circulation. Cardiovascular Quality and Outcomes·Emmanuel AkintoyeDariush Mozaffarian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.