The Effect of OnabotulinumtoxinA on Aura Frequency and Severity in Patients With Hemiplegic Migraine: Case Series of 11 Patients

Headache
Tiffany Y ChenCarrie E Robertson

Abstract

OnabotulinumtoxinA has been demonstrated to be effective for the preventive treatment of headache in individuals with chronic migraine and has been approved and recommended for this patient population. While the therapeutic effect of onabotulinumtoxinA on migraine headache is well documented, there is limited information on the effect of onabotulinumtoxinA on migraine aura. Given the prolonged and often debilitating nature of aura in patients with hemiplegic migraine, our group sought to examine the effect of onabotulinumtoxinA on aura frequency and severity in this specific subset of migraine patients. All clinical notes from July 1, 1994 to December 1, 2017 at our institution were retrospectively reviewed to identify patients diagnosed with hemiplegic migraine who received at least one set of onabotulinumtoxinA injections. Thirty-four patients were identified; and of those, 23 were excluded due to incomplete documentation regarding aura symptoms at follow-up visits. The clinical notes of the remaining 11 patients (4 with familial hemiplegic migraine [FHM] and 7 with sporadic hemiplegic migraine [SHM]) were reviewed, and the frequency and description of their headaches and aura before and after receiving onabotulinumtoxinA wer...Continue Reading

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Citations

Jun 26, 2020·Journal of Child Neurology·Raymundo Marcelo, Brin Freund
May 21, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Vincenzo Di StefanoPasquale Parisi
Apr 4, 2021·Children·Hannah F J Shapiro, Alyssa Lebel
Jul 3, 2021·Journal of Clinical Medicine·Jason C RayManjit Matharu

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