The effect of oophorectomy on mechanical properties of rabbit cerebral and coronary isolated small arteries

American Journal of Obstetrics and Gynecology
V B HansenA Forman

Abstract

Our purpose was to study the effect of oophorectomy on the passive and active mechanical characteristics of rabbit small cerebral and small coronary arteries. Ring preparations of small cerebral and small coronary arteries from rabbits that had undergone oophorectomy and sham operation were mounted on myographs 6 weeks after operation. Experiments were performed as follows. (1) concentration-response relations for vasopressin (10(-11) to 10(-7) mol/L), U46619 (10(-10) to 10(-6) mol/L), 5-hydroxytryptamine (10(-7) to 10(-5) mol/L), and endothelin (10(-13) to 10(-7) mol/L); (2) relaxing effects of acetylcholine (10(-8) to 10(-4) mol/L); (3) length-tension relations after addition of high potassium (124 mmol/L), vasopressin (10(-7) mol/L), and a mixture composed of potassium (124 mmol/L), vasopressin (10(-7) mol/L), and prostaglandin F 2 alpha (10(-5) mol/L); (4) calculation of vessel morphologic features and determination of hydroxyproline as a measure of collagen content. Oophorectomy did not influence basal tone, relaxant effects of acetylcholine, vessel morphologic features, elastic characteristics, or hydroxyproline content of the vessels. However, in cerebral arteries at a normalized lumen diameter, oophorectomy induced a ma...Continue Reading

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Citations

Jul 21, 2004·Climacteric : the Journal of the International Menopause Society·S H PedersenB Ottesen
Aug 8, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Vincent M TutinoHui Meng
Jun 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·V B HansenE S Hansen
Jan 12, 2008·Menopause : the Journal of the North American Menopause Society·Susan H PedersenBent Ottesen
Apr 7, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Susan Helene PedersenBent Ottesen

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