The effect of opioids on the development of postoperative intra-abdominal adhesions.

Digestive Diseases and Sciences
Amir Khorram-ManeshDick Delbro

Abstract

People addicted to opium rarely develop intra-abdominal adhesions after abdominal surgery. We aimed to evaluate the effect of opium or morphine on preventing postoperative adhesions in rats. Sixty-three rats were randomly divided into a control group, opium-addicted group, and morphine-addicted group in a double-blind study. Drug dependency was checked by using naloxone. Animals were then operated on and the cecum was abraded. At reoperation 3 weeks later the magnitude of adhesions was evaluated by a scoring system. There was a significant difference between the control, opium-addicted, and morphine-addicted groups with regard to the length (P < .001), thickness (P < .05), and severity of adhesions (P < .05). Opium or morphine reduces the severity of postoperative adhesions. Elucidation of the opioid receptor(s) involved in this process would enable the use of selective ligands and offer a pharmacologic strategy in preventing adhesion formation.

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Citations

Feb 7, 2007·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Hasan Fehmi KucukHuseyin Akyol
Dec 29, 2009·The Journal of Surgical Research·Brian C Ward, Alyssa Panitch
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Aug 11, 2015·Current Problems in Surgery·Robel T BeyeneAdrian Barbul
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May 4, 2021·The Journal of Surgical Research·Nihat AksakalUmut Barbaros

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