The effect of oral administration of calcium and magnesium on intestinal oxalate absorption in humans

Isotopes in Environmental and Health Studies
Susanne VossGerd E von Unruh

Abstract

Calcium oxalate (CaOx) urolithiasis is the most common urinary stone disease (70-75 % of all stones consist of CaOx in countries with western diet). Oxalate is the most lithogenic substance in CaOx crystallisation in urine. Oxalate is either synthesized within the body or absorbed from food. As oxalate is not metabolized in the human body, it appears unchanged in urine. Conventional analysis methods cannot distinguish between endogenous and exogenous oxalate. Our [13C2]oxalate absorption test enabled measurement of intestinal oxalate absorption and quantification of the influence of Ca- and Mg-supplementation on it. The effects of the oral administration of these supplements were compared in order to obtain valid data for recommendations for CaOx urolithiasis patients. A 10 mmol supplement of both ions decreased the oxalate absorption significantly, calcium being more than twice as effective.

References

Jul 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·P M Zarembski, A Hodgkinson
May 1, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·R L RyallV R Marshall
Jan 1, 1982·Clinical Science·P C HallsonS Sulaiman
Aug 7, 1998·Urological Research·R P HolmesH O Goodman
Nov 21, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·G E von UnruhA Hesse
Feb 7, 2001·The Journal of Urology·M Liebman, G Costa
Apr 25, 2000·The Urologic Clinics of North America·D G Assimos, R P Holmes
Oct 7, 2000·Isotopes in Environmental and Health Studies·G E von UnruhA Hesse
Jan 11, 2002·The New England Journal of Medicine·Loris BorghiAlmerico Novarini
Apr 11, 2003·The Journal of Urology·L Joseph MeltonHorst Zincke
May 22, 2004·Journal of the American Society of Nephrology : JASN·Gerd E von UnruhAlbrecht Hesse

❮ Previous
Next ❯

Citations

Oct 20, 2005·Der Urologe. Ausg. A·M StraubL Rinnab
Sep 24, 2010·Urological Research·Roswitha SienerAlbrecht Hesse
Aug 5, 2015·Seminars in Arthritis and Rheumatism·Colin B LigonZsuzsanna H McMahan
Feb 24, 2005·Current Opinion in Urology·Michael Straub, Richard E Hautmann
Jul 25, 2019·Biological Trace Element Research·Jing WuTubao Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.