The effect of oral and parenteral vitamin D supplementation in the elderly: a prospective, double-blinded, randomized, placebo-controlled study.

Rheumatology International
Hakan SakalliAhmet Eftal Yucel

Abstract

Hypovitaminosis D in the elderly causes falls and fractures as a result of impaired neuromuscular functions and also may be a reason for nonspecific musculosceletal pain. The aim of this study is to investigate the benefits of a single dose per os or parenterally administrated vitamin D on increasing the quality of life and functional mobility and decreasing the pain in the elderly. The community-dwelling elderly subjects over 65 years age were included in the study. The subjects were given 300.000 IU Vitamin D via per os and parenteral route and assessed after 4 weeks. The serum creatinine, calcium, phosphorous, ALT, ALP, 24-h urine calcium excretion, PTH, and vitamin D levels, as well as VAS (visual analog scale) for pain assessment, functional mobility with TUG (timed up and go test) and quality of life with SF-36 before and after the treatment were evaluated. The serum vitamin D levels were measured by the RIA method. The subjects were divided into four groups each consisting of 30 subjects. The 1st group took i.m. vitamin D, the 2nd group took i.m. placebo, the 3rd group took p.o. vitamin D, and the 4th group took p.o. placebo. The mean age of all the participants was 70.1 ± 4.3 years. There was no difference in the age an...Continue Reading

References

Oct 1, 1985·The Journal of Clinical Investigation·J MacLaughlin, M F Holick
May 1, 1987·Calcified Tissue International·K S TsaiB L Riggs
Mar 21, 1998·Age and Ageing·S G ParkerC M Castleden
Sep 8, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M H Gannagé-YaredG Halaby
Aug 18, 2001·Age and Ageing·S J WaltersJ E Brazier
Jan 5, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mauro ZamboniOttavio Bosello
Jul 31, 2002·Age and Ageing·Jugdeep K DhesiTheresa J Allain
Dec 10, 2003·Mayo Clinic Proceedings·Gregory A Plotnikoff, Joanna M Quigley
Oct 27, 2004·Age and Ageing·Jugdeep K DhesiTheresa J Allain
Oct 11, 2005·Journal of Affective Disorders·Jay D Amsterdam, Justine Shults
Sep 11, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Sibel BasaranFusun Guler-Uysal
Sep 22, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Madelon L PetersInge Lamé

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Citations

Jun 19, 2013·International Journal of Rheumatic Diseases·Debashish Danda
Oct 15, 2013·International Journal of Rheumatic Diseases·Mahnaz SandoughiSogol Shahbakhsh
Nov 15, 2012·Annals of Family Medicine·Ferdinand SchreuderJohannes C van der Wouden
Oct 20, 2014·Inflammopharmacology·Michael C Powanda
Jun 6, 2015·Seminars in Arthritis and Rheumatism·Rainer H StraubRoberto Pacifici
Jan 28, 2014·The Lancet. Respiratory Medicine·Wim JanssensHannelie Korf
Jan 13, 2015·Journal of the Academy of Nutrition and Dietetics·Michelle R HoffmannDiana R Mager
May 18, 2016·Scandinavian Journal of Primary Health Care·Andreas ThörnebyElse Hellebö Johanson
Jun 18, 2016·Nutrients·Sigal TepperSofia Ish-Shalom
Jun 28, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Theresa Katharina SchäferThomas Meyer
Apr 4, 2017·Foot & Ankle Specialist·Benjamin R WilliamsSarah A Anderson
May 7, 2015·The Cochrane Database of Systematic Reviews·Sebastian StraubeR Andrew Moore
Apr 16, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Courtney BoydUNKNOWN HERB Working Group
Nov 20, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Malcolm D KearnsVin Tangpricha
Aug 19, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lise Sofie BislevLars Rejnmark

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