The effect of oral contraceptive pill for cycle scheduling prior to GnRH-antagonist protocol on IVF cycle parameters and pregnancy outcome.

Journal of Assisted Reproduction and Genetics
Haim PinkasJacob Farhi

Abstract

To evaluate the effect of oral contraceptive pills (OCP) pretreatment on IVF cycle outcome in GnRH-antagonist protocol. Retrospective cohort study. Major tertiary university-affiliated center. All patients treated with GnRH antagonist in our IVF unit during the last 3 years were included in the study. Overall 1,799 IVF cycles were performed. Of these, in 604 cycles OCP pretreatment was used prior to GnRH-antagonist for cycle scheduling. Patients were divided into two age groups-young group aged < or = 35 years and older group aged > or = 36 years. The young group underwent 927 cycles, 281 cycles with OCP pretreatment and 646 cycles without. The older group underwent 872 cycles, 323 cycles with OCP pretreatment and 549 cycles without. Data was analyzed within each age group. Treatment duration and total dose of FSH IU used for stimulation, number of oocytes retrieved, implantation and pregnancy rates. All OCP-pretreated cycles required significantly longer stimulation than non-pretreated cycles (young: 10.76 vs. 9.21 days; older: 10.48 vs. 8.73 days, respectively) and higher total dose of FSH IU (young: 3,210 IU vs. 2,565 IU; older: 4,973 IU vs. 3,983 IU, respectively). There were no other differences in cycle characteristics be...Continue Reading

References

Apr 2, 2002·Human Reproduction·Hesham Al-Inany, Mohamed Aboulghar

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Citations

Mar 19, 2013·Reproductive Biology and Endocrinology : RB&E·Alan B Copperman, Claudio Benadiva
Apr 3, 2012·Fertility and Sterility·Isabelle Cédrin-DurnerinUNKNOWN Groupe d'Etude en Médecine et Endocrinologie de la Reproduction
Oct 25, 2011·Reproductive Biomedicine Online·Jacob FarhiAvi Ben-Haroush
Dec 25, 2015·Journal of Assisted Reproduction and Genetics·Kemal OzgurKevin Coetzee
Dec 30, 2014·Frontiers in Public Health·Kathryn CoyneLeslie A Appiah
Jan 17, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Anat Hershko KlementAdrian Shulman
May 13, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jie LiWeiwei Luo

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