PMID: 428694Apr 1, 1979Paper

The effect of oral galactose on GIP and insulin secretion in man

Diabetologia
L M MorganV Marks

Abstract

The insulinotropic effect of 50 g galactose given orally to 5 normal volunteers on two occasions--once with and once without a period of hyperglycaemia produced by an intravenous glucose infusion--was studied. Oral galactose caused a rise in plasma GIP from fasting levels of 260 +/- 50 ng/l (mean +/- S.E.M.) to a maximum of 900 +/- 65 ng/l 30 min after ingestion, but in the presence of induced hyperglycaemia the GIP response was significantly diminished and delayed (maximum plasma GIP levels 595 +/- 110 ng/l at 45 min, p less than 0.05). The insulin response to galactose was greatly enhanced by IV glucose (mean area under plasma insulin curve with galactose alone 236.5 +/- 66.0, with galactose + IV glucose 451.9 +/- 81.6, p less than 0.025). The mean rise in plasma galactose was significantly lower in the presence of IV glucose (mean peak level 1.97 +/- 0.28 mmol/l with galactose alone, 0.69 +/- 0.16 mmol/l galactose + IV glucose, p less than 0.025). Oral galactose caused the release of GIP, which is powerfully insulinotropic in the presence of moderate hyperglycaemia. The lower plasma GIP and galactose levels observed following oral galactose in the presence of IV glucose may be accounted for either by postulating that insulin...Continue Reading

References

Feb 1, 1978·American Journal of Surgery·K R SirinekS Cataland
May 1, 1978·Annals of Clinical Biochemistry·L M MorganV Marks
Mar 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·K ShimaM Nishikawa
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Apr 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·D C KVAM

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Citations

Jul 1, 1992·Diabetes/metabolism Reviews·W Creutzfeldt, M Nauck
Sep 30, 1999·Gastroenterology Clinics of North America·S Y Kang, V L Go
May 1, 1988·Baillière's Clinical Endocrinology and Metabolism·J C Brown
Dec 1, 1991·The Proceedings of the Nutrition Society·V MarksR Elliott
May 1, 1980·The Journal of Clinical Investigation·C A VerdonkF J Service
Mar 1, 1983·Metabolism: Clinical and Experimental·C A WilliamsI Macdonald
Apr 7, 1979·Lancet·R H TaylorH Fielden
Jan 1, 1987·Diabetes/metabolism Reviews·R Ebert, W Creutzfeldt
May 4, 2011·Evolution & Development·Erik A SperlingKevin J Peterson
Aug 1, 1994·European Journal of Clinical Investigation·B GökeR Arnold

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