The Effect of Oral Phenazopyridine on Perioperative Voiding After Midurethral Slings (EPIPhANy Study)

Female Pelvic Medicine & Reconstructive Surgery
Omar Felipe Dueñas-GarciaMichael Kevin Flynn

Abstract

To determine the effect of preoperative oral phenazopyridine on postoperative voiding dysfunction in women undergoing a retropubic midurethral sling. A single-institution randomized clinical trial was performed from September 2015 to March 2017, comparing 200 mg of oral phenazopyridine versus no phenazopyridine in patients undergoing a retropubic midurethral sling under general anesthesia with no concomitant procedures. A power calculation indicated that we required at least 40 subjects per arm. Preoperative demographics, intraoperative medications, blood loss, and complications were recorded. A standardized voiding trial was performed before discharge. Voiding dysfunction was determined by the proportion of subjects who failed a postoperative voiding trial. Pain scores were obtained before and 2 to 3 hours after the surgical procedure. Patient characteristics and surgical data were compared using χ, Fisher exact test, or Wilcoxon rank sum test. Ninety-two subjects were enrolled in the study. Three patients cancelled their surgery and 1 had an intraoperative urethral injury, leaving 88 patients for the final analysis (44 per arm). Patient demographics showed no differences between groups. Phenazopyridine did not reduce the prop...Continue Reading

References

Jul 13, 2002·American Journal of Obstetrics and Gynecology·Steven KleemanMickey Karram
May 29, 2003·The Journal of Urology·Elizabeth A MillerGeorge D Webster
Aug 24, 2010·The Journal of Urology·James Q PulvinoMichael K Flynn
Mar 8, 2011·American Journal of Obstetrics and Gynecology·Charles AndersonLinda Brubaker
May 4, 2012·The New England Journal of Medicine·Charles W NagerUNKNOWN Urinary Incontinence Treatment Network
Sep 12, 2014·International Journal of Women's Health·Elizabeth J Geller
Oct 30, 2016·American Journal of Obstetrics and Gynecology·Christopher M RipperdaDavid D Rahn
Jul 12, 2016·Obstetrics and Gynecology·Katie PropstChristine LaSala
Sep 30, 2016·Female Pelvic Medicine & Reconstructive Surgery·Omar Felipe Dueñas-GarciaMichael Kevin Flynn

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Citations

Oct 4, 2020·Female Pelvic Medicine & Reconstructive Surgery·Deepali MaheshwariMichael Flynn
Apr 30, 2019·Female Pelvic Medicine & Reconstructive Surgery·Tania SierraMichael K Flynn
Feb 14, 2021·International Urogynecology Journal·Sallie McSwainSteven Swift

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