The effect of organotin compounds on gender specific androstenedione metabolism in the freshwater ramshorn snail Marisa cornuarietis

The Journal of Steroid Biochemistry and Molecular Biology
Gemma JanerC Porte

Abstract

In a recent study, we demonstrated that androstenedione was mainly converted to testosterone (T) and 5alpha-dihydrotestosterone (DHT) by digestive gland/gonad complex microsomal fractions isolated from male Marisa cornuarietis, whereas it was primarily metabolized to 5alpha-dihydroandrostenedione (DHA) by females. In the present work, the sexual dimorphic metabolism of androstenedione was further investigated, and attributed to a higher 17beta-hydroxysteroid dehydrogenase activity in males than in females. Thereafter, the hypothesis was tested that the metabolism of androstenedione might be affected by exposure to tributyltin (TBT) and triphenyltin (TPT), which are known to induce the development of imposex in several gastropod species. The in vitro metabolism of androstenedione, particularly the formation of DHA and DHT, was inhibited by both compounds. However, in vivo experiments showed no significant alteration in the metabolism of androstenedione in males, but a marginal (TBT) and a significant (TPT) inhibition of the formation of DHA in females exposed for 150 days to concentrations that had significantly induced the development of imposex. The ratio DHT+T/DHA, a possible indicator of metabolic androgenization, tended to ...Continue Reading

References

Jan 1, 1974·General and Comparative Endocrinology·D de LongcampM Drosdowsky
Jan 1, 1996·Critical Reviews in Toxicology·K Fent
Feb 28, 1998·Archives of Environmental Contamination and Toxicology·E OberdörsterG A LeBlanc
Nov 10, 2000·Peptides·E Oberdörster, P McClellan-Green
Apr 5, 2003·Environmental Health Perspectives·Meredith P GoodingGerald A LeBlanc
May 28, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Susan LoStephan Steckelbroeck
May 8, 2004·Molecular and Cellular Endocrinology·R MindnichJ Adamski
Feb 9, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Rémi Thibaut, Cinta Porte
Jun 1, 2005·General and Comparative Endocrinology·G JanerC Porte

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Citations

Dec 28, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Denise FernandesCinta Porte
Oct 14, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Angeliki LyssimachouCinta Porte
Dec 13, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Alessandra PagliaraniVittoria Ventrella

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