PMID: 7027709Oct 1, 1981Paper

The effect of ornithine-alpha-ketoglutarate on insulin and glucagon secretion in normal subjects

Acta Endocrinologica
J KrassowskiJ P Felber

Abstract

Ornithine-alpha-ketoglutarate (OAK), a drug commonly used in various catabolic states, was studied for its acute effects on endocrine pancreas. A 30-min infusion of OAK (20 g/m2) induced significant increases in insulin levels (from 15 through 60 min) and in glucagon levels (from 15 through 90 min). However, OAK-induced insulin and glucagon responses were lower than after a 0.5 g/kg arginine infusion. The fluctuations of blood glucose levels were much less marked during OAK infusion than during arginine and especially the late fall was less evident.

Citations

Feb 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M VaubourdolleO G Ekindjian
May 17, 2018·Physiological Reviews·Sofiya GanchevaMichael Roden
Jan 1, 1993·Nutrition Research Reviews·G K Grimble
Sep 11, 1992·International Journal of Sport Nutrition·L R BucciJ M Pivarnik
Sep 1, 1993·International Journal of Sport Nutrition·G M FogelholmM H Härkönen
Feb 1, 1985·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·U LeanderE Vinnars
Oct 1, 1987·Burns, Including Thermal Injury·M VaubourdolleJ Giboudeau

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