The effect of ovariectomy on learning and memory and relationship to changes in brain volume and neuronal density

The International Journal of Neuroscience
Jian SuBungorn Sripanidkulchai

Abstract

The loss of sex hormones in postmenopausal women has been suggested to be involved in cognitive degenerative diseases, such as Alzheimer's disease. In the present study, ovariectomized (OVX) and control rats were tested for 4 months in a Morris water maze (MWM) task to track their memory status. Thereafter, postmortem frozen brain sections were analyzed to determine if changes in brain area volumes and neuronal density were related to changes in cognitive ability. A modified artificial-land-mark-based method was used to assure the fidelity of the three dimensions (3D) reconstructed structures. Volumetric areas of the hippocampus, cortex, caudate putamen (cpu), and cerebellum were estimated from the reconstructions, and neuron densities of CA1 and CA3 subregions of the hippocampus were measured in an adjacent second series of Nissl-stained sections. Compared to the control rats, OVX rats displayed memory impairments, beginning in the second month after the ovariectomy (p < .05). Assessments at the end of the study demonstrated that OVX (compared to control) rats displayed reduced brain volume in the hippocampus and neocortex and in the brain as a whole. In contrast, when compared to controls, the volumes of cpu and cerebellum of...Continue Reading

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Citations

Jul 22, 2017·Neurobiology of Learning and Memory·Alyssa M SbisaMaarten van den Buuse
Nov 28, 2017·Diabetology & Metabolic Syndrome·Parvin BabaeiBahram Soltani Tehrani
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Nov 30, 2019·Frontiers in Behavioral Neuroscience·Anousheh Bakhti-SurooshWendy J Lynch
Nov 9, 2020·Hormones and Behavior·Alyssa F DeLarge, Peter J Winsauer

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