PMID: 32141858Mar 7, 2020Paper

THE EFFECT OF OXIDATIVE STRESS ON THE AUTONOMIC NERVOUS SYSTEM IN PATIENTS WITH LIVER CIRRHOSIS

Georgian Medical News
M AbrahamovychS Tolopko

Abstract

Aim - to investigate the effect of oxidative stress on the autonomic nervous system state in patients with liver cirrhosis. In a randomized way with the preliminary startification by the presence of LC 81 patients - 55 (67.9%) males, 26 (32.1%) females, aged 46.9±10.8 years were included to the study after the signing the informed cosent. All the patients underwent the comprehensive clinical laboratory and instrumental examination of all organs and systems in accordance with the requirements of the modern medicine.Among the indicators of redox homeostasis the content of malondialdehyde (MDA) and of catalase (CAT) were determined. The study of autonomic nervous system (ANS) status was carried out using the registration of heart rate variability (HRV) before and after the physical activity. The results were processed on a personal computer in Statistica 6.0, RStudio v. 1.1.442 and R Commander v.2.4-4 using descriptive statistics. The difference was considered statistically significant if p<0.05. The results of HRV time parameters analysis before the physical activity revealed that MDA content negatively correlated with mean duration of NN (RR) intervals (RRNN), standard deviation of NN intervals (SDNN), the square root of the mea...Continue Reading

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