The effect of oxytocin on the contractile force of human atrial trabeculae

Anesthesia and Analgesia
O P RosaegR S Labow

Abstract

We performed an in vitro examination of the inotropic effect of oxytocin, chlorobutanol, and their combination to assess the effect of these drugs on the contractile force of human atrial trabeculae. Right atrial tissue samples were obtained during cardiac surgery with cardiopulmonary bypass. Trabeculae of the atrial appendage were dissected and mounted on muscle stands in a modified Krebs-Henseleit buffer bath. This isometric atrial trabecula preparation was subjected to a cumulative pharmacological protocol of either pure oxytocin, pure chlorobutanol, or a combination of the two drugs until no further change occurred in either developed force or resting force of the atrial trabeculae. A "no drug" buffer solution was used to assess the effect of time on the natural decay of the atrial preparation. The relative developed force of oxytocin plus chlorobutanol solution and pure chlorobutanol were similar in magnitude and lower than that in control experiments (P < 0.001) Pure oxytocin did not change the contractile force of atrial tissue. We conclude that pure oxytocin does not have a cardiodepressive effect in this human atrial preparation. Chlorobutanol has a negative inotropic effect, which is of a magnitude similar to a combin...Continue Reading

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Citations

Aug 26, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K C DennehyJ P Sylvain
Feb 19, 2015·Pharmacology Research & Perspectives·Yusheng QuHugo M Vargas
Nov 6, 2012·Revista española de anestesiología y reanimación·J R Ortiz-GómezL Bermejo-Albares
Nov 3, 2010·International Journal of Obstetric Anesthesia·C Y YangG C Tao
Jul 16, 2010·International Journal of Obstetric Anesthesia·R A DyerA Dresner
Dec 3, 2015·Revista brasileira de anestesiologia·Eduardo Tsuyoshi YamaguchiMarcelo Luis Abramides Torres
Oct 7, 2003·Pain·Craig A KornickPaolo L Manfredi
Jun 28, 2016·Brazilian Journal of Anesthesiology·Eduardo Tsuyoshi YamaguchiMarcelo Luis Abramides Torres
Jan 15, 2002·The Australian & New Zealand Journal of Obstetrics & Gynaecology·A U LokugamageC H Rodeck

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