Abstract
Due to its strong oxidation activity, ozone has been well known to kill bacteria and exert toxic effects on human tissues. At the same time, ozone is being used for the treatment of diseases such as inflammatory bowel disease in some European countries. However, the use of ozone for therapeutic purposes, despite its strong toxic effects, remains largely unexplored. Interestingly, we found that intrarectal administration of ozone gas induced transient colonic epithelial cell damage characterized by the impairment of cell survival pathways involved in DNA replication, cell cycle, and mismatch repair. However, the damaged cells were rapidly extruded from the epithelial layer, and appeared to immediately stimulate turnover of the epithelial layer in the colon. Therefore, it is possible that ozone gas is able to trigger damage-induced rapid regeneration of intestinal epithelial cells, and that this explains why ozone does not cause harmful or persistent damage in the colon.
References
Sep 1, 1992·Medical Hypotheses·V Bocci
Oct 1, 1991·Antiviral Research·M T Carpendale, J K Freeberg
Jan 1, 1990·Free Radical Biology & Medicine·M G Mustafa
Apr 1, 1981·The Anatomical Record·M Bjerknes, H Cheng
Jul 1, 1995·Free Radical Biology & Medicine·F HernándezR Wong
Jan 10, 2002·Gastroenterology·Emiko MizoguchiAtul K Bhan
Jun 5, 2002·Annual Review of Biochemistry·Stephen P Bell, Anindya Dutta
Jul 10, 2003·Gastroenterology·Emiko MizoguchiAtsushi Mizoguchi
Dec 3, 2005·The New England Journal of Medicine·Vivian G LooAndré Dascal
Aug 8, 2006·Toxicology and Applied Pharmacology·Velio Bocci
Jul 17, 2007·Annual Review of Genetics·R A Sclafani, T M Holzen
Mar 5, 2009·Medicinal Research Reviews·Velio BocciIacopo Zanardi
Sep 16, 2009·Blood Purification·Velio Bocci, Nicola Di Paolo
May 8, 2010·Renal Failure·Suzi DemirbagAhmet Korkmaz
May 15, 2010·Diabetology & Metabolic Syndrome·Mohamed D MorsySherif I Zalat
Jun 10, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Neil GuptaAlexander J Kallen
Jan 1, 2011·Journal of Natural Science, Biology, and Medicine·A M Elvis, J S Ekta
Apr 17, 2012·Nature·George T EisenhofferJody Rosenblatt
Jun 13, 2012·Gut·Claudia GüntherChristoph Becker
Jan 1, 2011·Diabetes & Metabolic Syndrome·Velio BocciValter Travagli
Feb 26, 2015·The New England Journal of Medicine·Fernanda C LessaL Clifford McDonald
Aug 4, 2016·Free Radical Research·Giuseppe ValacchiValter Travagli
Feb 10, 2017·Anticancer Research·Margherita LuongoGennaro Gaudino
Jul 25, 2017·Journal of Biomaterials Science. Polymer Edition·Carolina Fracalossi RediguieriTerezinha de Jesus Andreoli Pinto
Sep 3, 2017·Bioscience Reports·Weirong XiaoXiaopeng Xu