PMID: 1383865Sep 1, 1992

The effect of p-chloroamphetamine and p-chlorophenylalanine on the level of thyrotropin-releasing hormone and its receptors in some brain structures and lumbar spinal cord of the rat

Neuropeptides
E PrzegalińskiK Gołembiowska

Abstract

The concentration of thyrotropin-releasing hormone (TRH) and the density and affinity of TRH receptors were examined in the ventral and dorsal lumbar spinal cord, nucleus accumbens and striatum of rats with the 5-hydroxytryptamine (5-HT) nerve terminal destroyed with p-chloroamphetamine (PCA), or in animals treated with the inhibitor of 5-HT synthesis p-chlorophenylalanine (PCPA). PCA (2 x 10 mg/kg i.p., 9 and 8 d before killing) and PCPA (3 x 300 mg/kg i.p., 72, 48 and 24 h before killing)--either of them dramatically diminishing the 5-HT and 5-HIAA concentrations in all the examined structures--reduced the TRH level and increased the density of TRH receptors in the ventral lumbar spinal cord. PCPA also reduced the TRH content in the nucleus accumbens. The PCA-induced reduction in the TRH level and increase in the density of TRH receptors in the ventral lumbar spinal cord were significantly attenuated by citalopram (2 x 20 mg/kg i.p., 30 min before PCA), a selective inhibitor of 5-HT uptake. Our results constitute a further proof that coexistence of TRH and 5-HT takes place in the ventral lumbar spinal cord and then indicate that other form(s) of relationship between 5-HT and TRH may exist in some parts of the central nervous ...Continue Reading

References

Sep 21, 2001·Physiology & Behavior·G M HolmesM S Beattie
Jul 12, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marta Kot, Władysława A Daniel
May 1, 1997·The Journal of Laboratory and Clinical Medicine·H KanaiT Naruse
Aug 1, 1995·Journal of Neurosurgery·K D PostP J Catalano
Jan 1, 1996·Acta neurochirurgica·H KobayashiT Kubota

Citations

Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Hyttel
Dec 3, 1981·European Journal of Pharmacology·R F GilbertP C Emson
Jan 1, 1982·Neuroscience·R F GilbertA A Verhofstad
Nov 25, 1983·European Journal of Pharmacology·N A SharifG R Breese
Dec 1, 1983·Regulatory Peptides·N A Sharif, D R Burt

Related Concepts

Brain
Lentiform Nucleus Structure
Fenclonine Hydrobromide
Synaptic Receptors
p-Chloroamphetamine
Fenclonine, (D)-Isomer
Nucleus Accumbens
Hydroxyindoleacetic Acid
Rats, Wistar
Proterelin Tartrate Hydrate

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