PMID: 9176559May 1, 1997Paper

The effect of paclitaxel on the radiosensitivity of gynecological tumor cells

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
M Rave-FränkR Fietkau

Abstract

Paclitaxel, a natural product from Taxus brevifolia, is a microtubule stabilizing agent, which has been shown to block different cells in the G2/M phase of the cell cycle and consequently, to modulate their radioresponsiveness. Our aim was to test the cytotoxic and radiosensitizing potential of paclitaxel, with respect to different gynecological tumors with varying radiosensitivities. We performed clonogenic assays and flow cytometry on 2 cell lines, MCF-7 (breast) and CaSki (cervix) cells, and on 2 primary ovarian tumor samples (OC-I and OC-II). The cells were irradiated with 200 kV X-rays, radiation doses of up to 8 Gy were applied either as single doses or in 2 Gy fractions. Paclitaxel concentrations varied from 0.07 to 700 nM, incubation times varied from 3 to 120 h. Paclitaxel alone changed the cell cycle distribution of the cells tested and was cytotoxic in a time and concentration dependent manner. When combined with radiation, most schedules resulted in additive effects of the combined treatments. However, for MCF-7 cells, when 7 nM paclitaxel, applied 24 h before irradiation, were combined with fractionated irradiation a supra-additive effect with a SER of 1.2 was found. For CaSki cells, under comparable conditions the...Continue Reading

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Citations

Nov 11, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·F WenzK J Weber
May 26, 2006·Radiation Oncology·Myrna CandelariaAlfonso Dueñas-Gonzalez
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Nov 3, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Premalatha Balachandran, Rajgopal Govindarajan
Mar 9, 2010·Drugs·Alfonso Dueñas-GonzálezDéborah Martínez-Baños
Mar 29, 2001·International Journal of Cancer. Journal International Du Cancer·O PradierH Schmidberger

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