The effect of Paf antagonists on bronchial hyperresponsiveness induced by Paf, propranolol or indomethacin

British Journal of Pharmacology
E J DixonC P Page


1. Intravenous administration of platelet activating factor, Paf (600 ng kg-1 h-1) to ventilated anaesthetised guinea-pigs induced bronchial hyperresponsiveness to i.v. acetylcholine. 2. Pretreatment of ventilated, anaesthetised guinea-pigs with the beta-adrenoceptor antagonist, propranolol, or the non-steroidal anti-inflammatory drug, indomethacin, induced bronchial hyperresponsiveness to i.v. histamine. 3. Paf-induced bronchial hyperresponsiveness was significantly attenuated by pretreatment with three different Paf antagonists, CV-3988, BN 52021 and WEB 2086. 4. Pretreatment of guinea-pigs with CV-3988, BN 52021 or WEB 2086 at doses inhibiting Paf-induced bronchial hyperresponsiveness, had no significant effect on propranolol or indomethacin-induced bronchial hyperresponsiveness. 5. It is suggested that bronchial hyperresponsiveness induced by propranolol or indomethacin is not secondary to Paf release in the guinea-pig.


Jul 1, 1979·British Journal of Pharmacology·J MacLagan, U M Ney
Oct 1, 1975·British Journal of Clinical Pharmacology·C Skinner, K N Palmer
Feb 1, 1986·Lancet·P J Barnes
Jun 1, 1988·The American Review of Respiratory Disease·D N RobertsonP J Barnes
Apr 1, 1987·British Journal of Pharmacology·P J BarnesD N Robertson
Feb 1, 1988·Trends in Pharmacological Sciences·C P Page
Jan 1, 1988·The Journal of Allergy and Clinical Immunology·C P Page
Jun 1, 1988·British Journal of Pharmacology·H W Mitchell, J J Adcock
Jan 1, 1987·Agents and Actions. Supplements·M Schmitz-SchumannC Virchow
Nov 1, 1986·The Journal of Allergy and Clinical Immunology·F E HargreaveE E Daniel
Jun 1, 1987·The American Review of Respiratory Disease·B W ChristmanJ R Snapper
Sep 1, 1987·British Journal of Pharmacology·D N Robertson, C P Page
Sep 23, 1987·European Journal of Pharmacology·H W Mitchell, J Adcock
Sep 1, 1966·The American Journal of Cardiology·R S MCNEILL, C G Ingram
Aug 1, 1983·British Journal of Pharmacology·U M Ney
Apr 25, 1983·Life Sciences·Z TerashitaK Nishikawa
Jun 1, 1980·British Journal of Pharmacology·J J Adcock, L G Garland


Jul 9, 1991·European Journal of Pharmacology·T IwamaS Tanaka
Jan 7, 1992·European Journal of Pharmacology·S L UnderwoodD Raeburn
Mar 1, 1991·The American Review of Respiratory Disease·C J Meade, H Heuer
Aug 8, 2007·Pharmacology & Therapeutics·Richard A BondC P Page
Jan 1, 1991·Annals of the New York Academy of Sciences·R D Krell, M McCarthy

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.