The effect of Paf antagonists on bronchial hyperresponsiveness induced by Paf, propranolol or indomethacin

British Journal of Pharmacology
E J DixonC P Page

Abstract

1. Intravenous administration of platelet activating factor, Paf (600 ng kg-1 h-1) to ventilated anaesthetised guinea-pigs induced bronchial hyperresponsiveness to i.v. acetylcholine. 2. Pretreatment of ventilated, anaesthetised guinea-pigs with the beta-adrenoceptor antagonist, propranolol, or the non-steroidal anti-inflammatory drug, indomethacin, induced bronchial hyperresponsiveness to i.v. histamine. 3. Paf-induced bronchial hyperresponsiveness was significantly attenuated by pretreatment with three different Paf antagonists, CV-3988, BN 52021 and WEB 2086. 4. Pretreatment of guinea-pigs with CV-3988, BN 52021 or WEB 2086 at doses inhibiting Paf-induced bronchial hyperresponsiveness, had no significant effect on propranolol or indomethacin-induced bronchial hyperresponsiveness. 5. It is suggested that bronchial hyperresponsiveness induced by propranolol or indomethacin is not secondary to Paf release in the guinea-pig.

References

Jul 1, 1979·British Journal of Pharmacology·J MacLagan, U M Ney
Oct 1, 1975·British Journal of Clinical Pharmacology·C Skinner, K N Palmer
Feb 1, 1986·Lancet·P J Barnes
Jun 1, 1988·The American Review of Respiratory Disease·D N RobertsonP J Barnes
Apr 1, 1987·British Journal of Pharmacology·P J BarnesD N Robertson
Feb 1, 1988·Trends in Pharmacological Sciences·C P Page
Jan 1, 1988·The Journal of Allergy and Clinical Immunology·C P Page
Jun 1, 1988·British Journal of Pharmacology·H W Mitchell, J J Adcock
Jan 1, 1987·Agents and Actions. Supplements·M Schmitz-SchumannC Virchow
Nov 1, 1986·The Journal of Allergy and Clinical Immunology·F E HargreaveE E Daniel
Jun 1, 1987·The American Review of Respiratory Disease·B W ChristmanJ R Snapper
Sep 1, 1987·British Journal of Pharmacology·D N Robertson, C P Page
Sep 23, 1987·European Journal of Pharmacology·H W Mitchell, J Adcock
Sep 1, 1966·The American Journal of Cardiology·R S MCNEILL, C G Ingram
Aug 1, 1983·British Journal of Pharmacology·U M Ney
Apr 25, 1983·Life Sciences·Z TerashitaK Nishikawa
Jun 1, 1980·British Journal of Pharmacology·J J Adcock, L G Garland

Citations

Jul 9, 1991·European Journal of Pharmacology·T IwamaS Tanaka
Jan 7, 1992·European Journal of Pharmacology·S L UnderwoodD Raeburn
Mar 1, 1991·The American Review of Respiratory Disease·C J Meade, H Heuer
Aug 8, 2007·Pharmacology & Therapeutics·Richard A BondC P Page
Jan 1, 1991·Annals of the New York Academy of Sciences·R D Krell, M McCarthy

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