PMID: 3112804Jun 1, 1987

The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites

Prostaglandins, Leukotrienes, and Medicine
A Riedel, H J Mest

Abstract

Platelet-activating factor (PAF), 10(-11) mol decreased the threshold of ouabain induced arrhythmia in guinea-pigs. The thresholds inducing premature ventricular beats and ventricular flutter were statistically significantly decreased by 27.4% and 15.6%, respectively. BM 13.177 (30 mg/kg), a thromboxane receptor antagonizing substance, and esculetin (1.2 mg/kg), a lipoxygenase inhibitor, abolished this arrhythmogenic effect of PAF. Acetylsalicylic acid (10 mg/kg) showed only a tendency to inhibit the PAF effect. These results suggest that PAF could play a role in cardiac arrhythmias under special conditions and it supports the hypothesis that PAF action is mediated by the release of leukotrienes and thromboxane.

References

Jul 15, 1984·Experientia·G CamussiG Emanuelli
Mar 7, 1980·European Journal of Pharmacology·R Levi, J A Burke
Oct 14, 1982·Biochimica Et Biophysica Acta·K SekiyaS Arichi

Citations

Mar 15, 1997·Journal of Cellular Biochemistry·J XuP E Keeting
Feb 8, 2013·Current Heart Failure Reports·Paraskevi DetopoulouSmaragdi Antonopoulou
Dec 10, 1991·European Journal of Pharmacology·P Salinas, S Barrigón
Nov 1, 1989·Prostaglandins·A ErnstH J Mest
Jun 15, 1989·Hearing Research·A ErnstH J Mest
Mar 1, 1997·Journal of Lipid Mediators and Cell Signalling·G FeuersteinS Vonhof
Jun 23, 2005·Critical Reviews in Food Science and Nutrition·Paola VitaglioneVincenzo Fogliano
Mar 11, 2005·Autonomic & Autacoid Pharmacology·A T Demiryürek, S Demiryürek
Sep 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P MentzH J Mest
Mar 8, 2011·Experimental Biology and Medicine·Claudia PennaG Alloatti
Oct 4, 2000·Physiological Reviews·G MontrucchioG Camussi

Related Concepts

Esculetin
SK&F 95587
Eicosatetraenoic Acids
Cardiac Arrhythmia
Zorprin
Antithrombotic Agents
Cavia porcellus
Ouabain
Platelet Activating Factor
Sulfonamides

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