PMID: 2510903Sep 18, 1989Paper

The effect of pancreatic islet transplantation and insulin therapy on neuroaxonal dystrophy in sympathetic autonomic ganglia of chronic streptozocin-diabetic rats

Brain Research
R E SchmidtD W Scharp

Abstract

The frequency of neuroaxonal dystrophy was determined in the superior mesenteric/celiac sympathetic ganglia in a streptozocin-treated rat model of diabetic autonomic neuropathy. Dystrophic axonopathy was increased 5- to 6-fold in 9-month untreated diabetics compared to age-matched controls. Pancreatic islet transplantation therapy or daily insulin administration prevented the development of dystrophic axonopathy. Transplantation of islets after 6 months of diabetes, a time at which dystrophic axonopathy is well developed, resulted in nearly complete resolution of the neuropathy within 3 months.

References

Feb 1, 1988·Transplantation·J A van der VlietD E Sutherland
Sep 1, 1986·Journal of Neuropathology and Experimental Neurology·R E Schmidt, S B Plurad
Jul 1, 1983·Journal of Neuropathology and Experimental Neurology·R E SchmidtC W Modert
Sep 1, 1982·Diabetes·R E Schmidt, D W Scharp

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Citations

Oct 1, 1991·Journal of the Neurological Sciences·S T BritlandK Federlin
Jun 17, 2004·Journal of Neuropathology and Experimental Neurology·Robert E SchmidtAnders A F Sima
Mar 14, 2001·Journal of Neuropathology and Experimental Neurology·R E SchmidtE Escandon
Nov 7, 1999·The American Journal of Pathology·R E SchmidtM S Miller

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