PMID: 1492Nov 1, 1975

The effect of pancuronium on myocardial contraction and catecholamine metabolism

The Journal of Pharmacy and Pharmacology
A D IvankovichB Zahed

Abstract

The effects of pancuronium bromide infusion on the uptake and release of [14C] noradrenaline (14C-NA) by the isolated, perfused rat heart and on the chronotropic and inotropic activity of the isolated heart were evaluated. Hearts were removed from animals under light ether anaesthesia, transferred to a modified Langendorff perfusing apparatus and perfused with Krebs-Ringer bicarbonate solution at a rate of 5 ml min-1. The effect of pancuronium on the uptake of noradrenaline was determined by perfusing hearts for 5 min with perfusate containing various concentrations of pancuronium and 200 ng ml-1 of 14C-NA. After 5 min pancuronium-treated hearts contained less 14C-NA. The degree of reduced uptake increased with increasing concentrations of pancuronium. In addition, the combination of pancuronium perfusion and electrical stimulation (15 mA for 10 ms at 4 Hz) blocked the 50 min uptake of 14C-NA by the heart to a greater degree than either factor separately. The release of noradrenaline was determined after perfusing hearts with 14C-NA followed by perfusion with solution containing pancuronium but no 14C-NA for 1 h. Pancuronium infusion did not significantly alter the release of 14C-NA from the heart after 1 h of perfusion. The in...Continue Reading

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Citations

Jan 1, 1981·Canadian Anaesthetists' Society Journal·A L Pauca, P Skovsted
Nov 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D H SethnaF G Estafanous
May 1, 1986·Canadian Anaesthetists' Society Journal·D H SethnaF G Estafanous
Mar 1, 1986·Canadian Anaesthetists' Society Journal·P A KapurW Flacke
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May 1, 1993·Acta Anaesthesiologica Scandinavica·K OmoteA Namiki
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Jul 6, 2014·Veterinary Anaesthesia and Analgesia·Kristoffer GrongGeir O Dahle

Related Concepts

Electric Stimulation Technique
Heart
Myocardial Contraction
Myocardium
Norepinephrine, (+, -)-Isomer
Pancuronium Curamed

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