The effect of parathyroidectomy on hematocrit and erythropoietin dose in patients on hemodialysis

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
R Rault, M Magnone

Abstract

Hyperparathyroidism has been implicated as a cause for resistance to erythropoietin therapy, based on a limited number of studies. The authors retrospectively surveyed the effects of parathyroidectomy on hematocrit and erythropoietin dose in patients with end-stage renal disease. The study group included 10 patients (4 men, 6 women) on long-term hemodialysis, 9 of whom were receiving erythropoietin intravenously during dialysis. Parathyroidectomy resulted in a decrease in mean parathormone levels from 15 times normal preoperatively to 2.3 times normal at follow-up. The hematocrit values increased, and the weekly erythropoietin dose decreased significantly when values 1 month before surgery were compared with those 6 months after surgery. From this, the authors conclude that secondary hyperparathyroidism is a cause of worsening anemia and increased erythropoietin requirements in patients on hemodialysis, and that parathyroidectomy is effective in reversing these abnormalities.

Citations

Feb 28, 2009·World Journal of Surgery·Yoshihiro TominagaNobuaki Uno
Jul 20, 2007·Journal of the American Society of Nephrology : JASN·Kyle D RudserBryan Kestenbaum
Oct 7, 2017·Current Opinion in Nephrology and Hypertension·Keith E Eidman, James B Wetmore
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