PMID: 11910527Mar 23, 2002Paper

The effect of partial vitrectomy on blood-ocular barrier function in the rabbit

Current Eye Research
W H GarnerG Graff

Abstract

To compare ocular vascular permeability in the rabbit after vitrectomy as assessed by contrast-enhanced magnetic imaging (CE-MRI) and measurements of aqueous and vitreous humor protein concentration. Partial vitrectomies were performed, irrigating with BSS or BSS PLUS. Post-operative vascular leakage was determined by CE-MRI following intravenous administration of gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA). Aqueous and vitreous protein concentrations were quantified by standard biochemical assay. ERG evaluations were performed on postoperative days 1, 3, and 7. Using BSS as irrigant, breakdown of the inner blood-retinal barrier (BRB) occurred in 4/7 eyes on post-operative day 1. The rate of Gd-DTPA leakage was significantly greater on postoperative day 1 than that in unoperated, control eyes, but declined approximately 50% by day 3. At both time points, outer BRB breakdown was restricted to the sclerotomy wounds. No BRB leakage was detectable in control eyes. Blood-aqueous barrier (BAB) leakage was bilateral on day 1. Significantly greater Gd-DTPA leakage occurred in the operated eye than in the nonsurgical contralateral eye. On day 3, approximately 40% bilateral reduction in leakage indicated resolution of BAB lea...Continue Reading

References

Aug 1, 1979·American Journal of Ophthalmology·L C MoorheadC A Garcia
Jan 1, 1991·Journal of Ocular Pharmacology·P S Kulkarni
Jan 1, 1991·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·G W Blankenship
Jan 1, 1990·Journal of Ocular Pharmacology·W G Unger
Feb 15, 1988·American Journal of Ophthalmology·S de BustrosB M Glaser
Dec 1, 1987·Current Eye Research·M A Saornil Alvarez, J C Pastor Jimeno
Jan 1, 1983·Archives of Ophthalmology·D R SandersG A Peyman
Apr 1, 1995·Klinische Monatsblätter für Augenheilkunde·F Körner, M Böhnke
Nov 1, 1995·Current Eye Research·S G ElnerR M Strieter
Jan 1, 1997·European Radiology·L ManfréR Lagalla
Apr 16, 1998·Progress in Retinal and Eye Research·H NagasakiM Mochizuki
May 30, 1998·Seminars in Ophthalmology·N Tachi
Jul 23, 1999·Survey of Ophthalmology·W E Smiddy, H W Flynn

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Citations

May 17, 2011·Expert Review of Ophthalmology·Billy D Novosad, Michelle C Callegan
Feb 24, 2010·Ophthalmology·A Brock RollerJames C Folk
Dec 24, 2009·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Mohammad HamidGisèle Li
Apr 10, 2008·Retina·Karin Gjörloff WallenténFredrik Ghosh
Jan 11, 2008·NMR in Biomedicine·S Kevin LiEun-Kee Jeong
Jun 26, 2003·Experimental Eye Research·Marcia D OngMargaret H Garner

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