PMID: 6025320Jun 1, 1967Paper

The effect of passively administered antibody on antibody synthesis

The Journal of Experimental Medicine
F J DixonP J McConahey

Abstract

Suppression of the primary response of rabbits to intravenously administered KLH can be achieved with very small amounts of hyperimmune anti-KLH administered a day later since the rabbit apparently rapidly eliminates most of the KLH by nonimmunologic means. The amount of passive anti-KLH needed to achieve immunosuppression was directly proportional to the dose of injected antigen. Antibody passively administered as much as 6-8 days after antigen still can be strongly immunosuppressive, which suggests that the antibody must be reacting with immunogen in or on responding cells or perhaps in the process of transfer between cells. There was no evidence that the presence of passively administered hyperimmune anti-KLH prior to the injection of antigen had any immunosuppressive action beyond the direct neutralization of the injected antigen. When KLH was injected in Freund adjuvant, anti-KLH incorporated with the KLH in the adjuvant was much more efficient in causing immunosuppression than anti-KLH given intravenously. The primary responses to 2 mg KLH given intravenously and 2 microg given in adjuvant reached approximately equal peaks and were suppressible by comparable amounts of intravenously administered anti-KLH. Two observations...Continue Reading

References

Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
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Citations

Apr 14, 1984·Lancet·A Fateh-MoghadamR G Geursen
Jun 21, 1969·Nature·E R UnanueM Bedford
Oct 23, 1980·The New England Journal of Medicine·E R Unanue
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton
Feb 1, 1968·The Journal of Experimental Medicine·V S Byers, E E Sercarz
May 1, 1968·The Journal of Experimental Medicine·P J McConaheyF J Dixon
Jul 1, 1968·The Journal of Experimental Medicine·C Henry, N K Jerne
May 1, 1971·The Journal of Experimental Medicine·C S PincusV Nussenzweig
Jan 1, 1972·The Journal of Experimental Medicine·R A LernerF J Dixon
Sep 1, 1971·Journal of Medical Genetics·J Bradley, C J Elson
Apr 1, 1972·Postgraduate Medical Journal·C A Clarke
Apr 1, 1989·Transfusion Medicine Reviews·L K Boshkov, J G Kelton
Jul 29, 2015·Biochemical Pharmacology·Jie Luo, Jon Lindstrom
Sep 5, 2012·Autoimmunity Reviews·Leslie P CousensAnne S De Groot
Jan 1, 1972·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·C HammerW Brendel
Feb 1, 1969·Arthritis and Rheumatism·J C Brown, W V Epstein
Aug 21, 2020·Integrative and Comparative Biology·Chloe C JosefsonWendy R Hood
Oct 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie Luo, Jon Lindstrom
Jul 6, 1968·Lancet·C A Clarke

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