The effect of paternal age on fetal birth outcomes

American Journal of Men's Health
Amina P AlioAlfred K Mbah

Abstract

Research investigating the role of paternal age in adverse birth outcomes is limited. This population-based retrospective cohort study used the Missouri maternally linked data set from 1989 to 2005 to assess whether paternal age affects fetal birth outcomes: low birth weight (LBW), preterm birth (PTB), stillbirth, and small size for gestational age (SGA). We examined these outcomes among infants across seven paternal age-groups (<20, 20-24, 25-29, 30-34, 35-39, 40-45, and >45 years) using the generalized estimating equation framework. Compared with infants born to younger fathers (25-29 years), infants born to fathers aged 40 to 45 years had a 24% increased risk of stillbirth but a reduced risk of SGA. A 48% increased risk of late stillbirth was observed in infants born to advanced paternal age (>45 years). Moreover, advanced paternal age (>45 years) was observed to result in a 19%, 13%, and 29% greater risk for LBW, PTB, and VPTB (very preterm birth) infants, respectively. Infants born to fathers aged 30 to 39 years had a lower risk of LBW, PTB, and SGA, whereas those born to fathers aged 24 years or younger had an elevated likelihood of experiencing these same adverse outcomes. These findings demonstrate that paternal age inf...Continue Reading

References

Aug 15, 1992·American Journal of Epidemiology·J D Parker, K C Schoendorf
Jun 19, 1986·The New England Journal of Medicine·R E Little, C F Sing
Apr 27, 1995·The New England Journal of Medicine·A M FraserR H Ward
Apr 1, 1994·British Journal of Obstetrics and Gynaecology·E G RaymondJ L Kiely
Jan 1, 1997·Obstetrics and Gynecology·R C Fretts, R H Usher
Dec 1, 1996·International Journal of Andrology·M F Vine
Mar 21, 1998·Clinical Obstetrics and Gynecology·G R AlexanderE Papiernik
Mar 29, 2000·JAMA : the Journal of the American Medical Association·M M AdamsD A Gilbertz
Apr 25, 2001·Archives of General Psychiatry·D MalaspinaE S Susser
Feb 22, 2002·American Journal of Perinatology·Ernest L AbelLarry Burd
May 16, 2002·Biology of the Neonate·Monica Miozzo, Giuseppe Simoni
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Dale FrankBenjamin Tycko
Jun 4, 2002·Human Reproduction·Elise de la Rochebrochard, Patrick Thonneau
Nov 1, 2002·Epidemiology·Susan HarlapYechiel Friedlander
Jul 31, 2003·Journal of Biosocial Science·Karine CôtéMartin L Lalumière
Dec 16, 2003·Obstetrics and Gynecology·Hamisu M SalihuGreg R Alexander
Feb 20, 2004·The New England Journal of Medicine·Pamela J SurkanSven Cnattingius
Jun 12, 2004·Human Reproduction Update·Bianca Kühnert, Eberhard Nieschlag
Aug 21, 2004·Human Reproduction·P AstolfiL A Zonta
Dec 8, 2004·American Journal of Epidemiology·Anne-Marie Nybo AndersenGeorge Davey Smith
Apr 21, 2005·American Journal of Epidemiology·Rémy SlamaShanna H Swan
Dec 15, 2005·JAMA : the Journal of the American Medical Association·Paula A BravemanSamuel Posner
Feb 16, 2006·Epidemiology·Paola AstolfiLaura Attinia Zonta
Mar 31, 2006·American Journal of Public Health·Nancy E Reichman, Julien O Teitler
Aug 2, 2006·Obstetrics and Gynecology·K KleinhausS Harlap
Sep 6, 2006·Archives of General Psychiatry·Abraham ReichenbergEzra Susser
Sep 16, 2006·Journal of Epidemiology and Community Health·Isabelle BrayGeorge Davey Smith
Dec 14, 2006·Human Reproduction·Q YangM Walker
Jan 11, 2007·International Journal of Epidemiology·Xi-Kuan ChenMark Walker
Apr 4, 2007·Archives of Pediatrics & Adolescent Medicine·Lisa A CroenJudith K Grether
Aug 11, 2007·American Journal of Obstetrics and Gynecology·Lisanne PalomarLouis J Muglia
Feb 8, 2008·Human Reproduction·Xi-Kuan ChenMark C Walker
Apr 26, 2008·European Journal of Epidemiology·Jin Liang ZhuJørn Olsen
Oct 7, 2008·The Journal of Obstetrics and Gynaecology Research·Hamisu M SalihuRussell S Kirby
Jun 16, 2009·Maternal and Child Health Journal·Amina P AlioHamisu M Salihu
Jan 19, 2010·Maternal and Child Health Journal·Philip M BlumenshinePaula A Braveman
Jun 1, 2010·Journal of Community Health·Amina P AlioHamisu M Salihu
Nov 6, 2010·Maternal and Child Health Journal·Ambika KrishnakumarRichard Aubry

❮ Previous
Next ❯

Citations

Sep 24, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Michael Zitzmann
Aug 6, 2013·Asian Journal of Andrology·Jason R KovacLarry I Lipshultz
Apr 1, 2014·Maturitas·Stephanie BellocMoncef Benkhalifa
Jun 25, 2014·The Journal of Family Planning and Reproductive Health Care·Gerald Lawson, Richard Fletcher
Jan 15, 2016·Human Reproduction·N K GhumanM Choudhary
Mar 27, 2015·American Journal of Primatology·Monica H Ahsan, Gregory E Blomquist
May 1, 2015·Reproductive Biology and Endocrinology : RB&E·Rakesh SharmaRola F Turki
Mar 9, 2017·European Journal of Epidemiology·Stine Kjaer UrhojAnne-Marie Nybo Andersen
Apr 8, 2017·PLoS Genetics·Jingjing LiGary M Shaw
Nov 23, 2013·American Journal of Men's Health·Lauren Abla DoamekporLauren Juliette Ramos
Feb 3, 2018·Molecular Reproduction and Development·Ismail KaarouchOmar Sefrioui
Mar 8, 2018·Biology of Reproduction·Marta GòdiaStephen A Krawetz
May 19, 2018·Current Urology Reports·Daniel J Mazur, Larry I Lipshultz
Dec 7, 2018·Prenatal Diagnosis·Justin S BrandtElena Ashkinadze
Nov 2, 2018·BMJ : British Medical Journal·Hilary K Brown
May 18, 2016·Obstetrical & Gynecological Survey·Lena Sagi-DainMartha Dirnfeld
Dec 9, 2017·Maternal and Child Health Journal·Ying Meng, Susan W Groth
Mar 7, 2020·PloS One·Michelle M DenommeMandy G Katz-Jaffe
Nov 27, 2018·Reproductive Biology and Endocrinology : RB&E·Alessandro IlacquaAntonio Aversa
Jun 21, 2019·Obstetric Medicine·A KothariL Callaway
Oct 9, 2016·Journal of Perinatal Medicine·Rebecca J BaerLaura L Jelliffe-Pawlowski
Aug 7, 2019·Journal of Assisted Reproduction and Genetics·Robert J CarrasquilloNasser Al-Asmar
Sep 17, 2020·Biology·Paulina Nguyen-Powanda, Bernard Robaire
Dec 10, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Jonathan A MayoMichael L Eisenberg
Jan 6, 2021·EMBO Reports·Kaichi YoshizakiNoriko Osumi
Jan 8, 2021·BMC Pregnancy and Childbirth·Jing LiQing Liu
Nov 7, 2020·Scientific Reports·Meng Yuan TianHong Zhuan Tan
Mar 25, 2021·European Journal of Epidemiology·Hans K HvideKjell G Salvanes
Jun 8, 2021·Biology of Reproduction·Paulina Nguyen-Powanda, Bernard Robaire
Nov 14, 2020·Reproductive Biology and Endocrinology : RB&E·Iman HalvaeiNavid Esfandiari
Aug 30, 2021·Journal of Pediatric Nursing·Jenifer Palomo-OsunaEva María Padilla-Muñoz

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
A J WyrobekD Evenson
Asian Journal of Andrology
Zofnat Wiener-MegnaziMartha Dirnfeld
Human Reproduction Update
Gideon A Sartorius, E Nieschlag
© 2021 Meta ULC. All rights reserved