The effect of PD-1 expression on tumor-associated macrophage in T cell lymphoma.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
J RuanD Zhou

Abstract

Our study aimed to explore the programmed death 1 (PD-1) expression on tumor-associated macrophage (TAM) in T cell non-Hodgkin lymphoma (T-NHL) and its relationship with lymphoma prognosis. The effect of PD-1 expression on the function of macrophages was also studied. Multispectral image quantitative analysis was applied for detecting PD-1 expression on macrophages in T cell lymphoma tissues. The Kaplan-Meier analysis was performed to evaluate the value of PD-1 expression of TAM in predicting the overall survival of T-NHL. PD-1 overexpression THP-1-derived macrophage was constructed and was cocultured with Jurkat cells to explore the effect of PD-1 on macrophage function. In 17 T cell lymphoma cases, the 1-year overall survival rate was significantly lower in patients with higher PD-1 expression on TAMs (0.25 vs 0.86, p < 0.05). After co-cultured with Jurkat cells, classically activated (M1)-related markers on PD-1 overexpressed macrophages were significantly lower than those on controls, while the expressions of alternatively activated (M2) related markers were similar. The PD-1 overexpressed macrophages showed inhibited phagocytosis (4.42% vs 40.7%, p < 0.001) and increased IL-10 secretion (144.48 pg/ml vs 32.32 pg/ml, p < 0....Continue Reading

References

Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Apr 1, 2008·Molecular Cancer Therapeutics·Nathan R MiselisAgnes B Kane
May 10, 2008·Seminars in Cancer Biology·Antonio SicaAlberto Mantovani
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raanan BergerArnon Nagler
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joaquim CarrerasElias Campo
Mar 10, 2009·Biochimica Et Biophysica Acta·Seth B CoffeltClaire E Lewis
Apr 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xin HuangAlfred Ayala
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Björn Engelbrekt WahlinEva Kimby
Sep 10, 2010·Disease Markers·S MuenstA Tzankov
Feb 22, 2012·Seminars in Cancer Biology·Astrid SchmiederKai Schledzewski
Oct 4, 2013·Immunotherapy·Roheena Z PanniDavid G DeNardo
Apr 15, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jacob P SmeltzerStephen M Ansell
Dec 9, 2014·The New England Journal of Medicine·Stephen M AnsellPhilippe Armand
Mar 22, 2015·Seminars in Cancer Biology·Marzenna BlonskaFrancisco Vega
Jul 19, 2015·Cancer Letters·Mark H ManninoYujiang Fang
Oct 16, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li ZhangLe-Xin Wang
Jun 9, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander M LesokhinJohn Timmerman
Feb 13, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·Y J KimW J Lee
Apr 24, 2017·Cellular Immunology·Kuntal Kanti GoswamiRathindranath Baral
Oct 25, 2017·British Journal of Cancer·Shweta Aras, M Raza Zaidi
Jan 11, 2018·Journal of Cellular Physiology·Abbas Shapouri-MoghaddamAmirhossein Sahebkar
May 11, 2018·Current Opinion in Hematology·Léa VerdièreKarin Tarte
Jun 5, 2018·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Mengjia SongYi Zhang

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